Impact of antiretroviral therapy on lipid metabolism of human immunodeficiency virus-infected patients: Old and new drugs  

作　　者：Joel da Cunha Luciana Morganti Ferreira Maselli Ana Carolina Bassi Stern Celso Spada Sérgio Paulo Bydlowski 

机构地区：[1]Laboratory of Genetics and Molecular Hematology(LIM31),University of Sao Paulo Medical School(FMUSP),Sao Paulo SP 05403-000,Brazil [2]Clinical Analysis Department,Health Sciences Center,Federal University of Santa Catarina(CCS/UFSC),Florianopolis SC 88040-900,BraZIL [3]Molecular Genetics and Biotechnology Department,Research Division,Pró-Sangue Foundation/Blood Center of Sao Paulo,Sao Paulo SP 05403-000,Brazil

出　　处：《World Journal of Virology》2015年第2期56-77,共22页世界病毒学杂志

基　　金：financially supported in the our laboratory with resources from The National Council of Technological and Scientific Development;the State of Sao Paulo Research Foundation;the National Institute of Science and Technology of Complex Fluids.

摘　　要：For human immunodeficiency virus(HIV)-infected patients, the 1990s were marked by the introduction of highly active antiretroviral therapy(HAART) representing a new perspective of life for these patients. The use of HAART was shown to effectively suppress the replication of HIV-1 and dramatically reduce mortality and morbidity, which led to a better and longer quality of life for HIV-1-infected patients. Apart from the substantial benefits that result from the use of various HAART regimens, laboratory and clinical experience has shown that HAART can induce severe and considerable adverse effects related to metabolic complications of lipid metabolism, characterized by signs of lipodystrophy, insulin resistance, central adiposity, dyslipidemia, increased risk of cardiovascular disease and even an increased risk of atherosclerosis. New drugs are being studied, new therapeutic strategies are being implemented, and the use of statins, fibrates, and inhibitors of intestinal cholesterol absorption have been effective alternatives. Changes in diet and lifestyle have also shown satisfactory results.For human immunodeficiency virus(HIV)-infected patients, the 1990s were marked by the introduction of highly active antiretroviral therapy(HAART) representing a new perspective of life for these patients. The use of HAART was shown to effectively suppress the replication of HIV-1 and dramatically reduce mortality and morbidity, which led to a better and longer quality of life for HIV-1-infected patients. Apart from the substantial benefits that result from the use of various HAART regimens, laboratory and clinical experience has shown that HAART can induce severe and considerable adverse effects related to metabolic complications of lipid metabolism, characterized by signs of lipodystrophy, insulin resistance, central adiposity, dyslipidemia, increased risk of cardiovascular disease and even an increased risk of atherosclerosis. New drugs are being studied, new therapeutic strategies are being implemented, and the use of statins, fibrates, and inhibitors of intestinal cholesterol absorption have been effective alternatives. Changes in diet and lifestyle have also shown satisfactory results.

关 键 词：Human immunodeficiency virus-1 infection Highly active antiretroviral therapy Protease inhibitors DYSLIPIDEMIA ATHEROSCLEROSIS LIPODYSTROPHY STATINS FIBRATES Diet LIFESTYLE 

分 类 号：R[医药卫生]