Infliximab for the treatment of pouchitis  

作　　者：Maddalena Zippi Claudio Cassieri Eleonora Veronica Avallone Roberta Pica 

机构地区：[1]Unit of Gastroenterology and Digestive Endoscopy, Sandro Pertini Hospital, 00157 Rome,Italy [2]Gastroenterology Unit, Department of Internal Medicine and Medical Specialties, " La Sapienza" University, 00161 Rome, Italy

出　　处：《World Journal of Clinical Cases》2013年第6期191-196,共6页世界临床病例杂志

摘　　要：Pouchitis is not a rare complication that develops after an ileal-pouch anastomosis, performed after colectomy in patients refractory to treatment or with complicated ulcerative colitis. This condition may become chronic and unresponsive to medical therapies, including corticosteroids, antibiotics and probiotics. The advent of biological therapies(tumor necrosis factor-α inhibitors) has changed the course of these complications. In particular, in these cases, infliximab(IFX) may represent a safe and effective therapy in order to avoid the subsequent operation for a permanent ileostomy. This article reviews the therapeutic effects of one of the most widely used anti-tumor necrosis factor-α molecules, IFX, for the treatment of complicated pouchitis(refractory to conventional treatment and/or fistulizing).Pouchitis is not a rare complication that develops after an ileal-pouch anastomosis, performed after colectomy in patients refractory to treatment or with complicated ulcerative colitis. This condition may become chronic and unresponsive to medical therapies, including corticosteroids, antibiotics and probiotics. The advent of biological therapies(tumor necrosis factor-α inhibitors) has changed the course of these complications. In particular, in these cases, infliximab(IFX) may represent a safe and effective therapy in order to avoid the subsequent operation for a permanent ileostomy. This article reviews the therapeutic effects of one of the most widely used anti-tumor necrosis factor-α molecules, IFX, for the treatment of complicated pouchitis(refractory to conventional treatment and/or fistulizing).

关 键 词：ILEAL pouch-anal ANASTOMOSIS INFLIXIMAB POUCHITIS Tumor necrosis factor-α ULCERATIVE colitis 

分 类 号：R57[医药卫生—消化系统]