Tumour induced osteomalacia due to a sinonasal hemangiopericytoma:A case report  

作　　者：Sophie A Jamal Brendan C Dickson Ina Radziunas 

机构地区：[1]Division of Endocrinology, Department of Medicine, University of Toronto, Toronto, ON M5G 1N8, Canada [2]Department of Pathology, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada [3]Multidisciplinary Osteoporosis Program, Women’s College Hospital, Toronto, ON M5S 1B1, Canada

出　　处：《World Journal of Clinical Cases》2013年第1期59-63,共5页世界临床病例杂志

摘　　要：Tumour induced osteomalacia(TIO) is a rare and often unrecognized cause of hypophosphatemia. We report on a case of TIO due to a hemangiopericytoma originating from the left nasal sinus. The patient was a 55-year-old male with a 3-year history of left hip pain and an undisplaced left hip fracture. Biochemical testing demonstrated low levels of serum phosphate and serum 1,25-dihydroxyvitamin D, and an elevated level of fibroblast growth factor 23. Octreotide scanning demonstrated uptake in the left nasal sinus area and a computed tomography scan revealed a left nasal sinus mass. The patient underwent surgical resection of the mass and histology was consistent with a sinonasal hemangiopericytoma. His serum phosphate levels normalized almost immediately after surgery and he had complete resolution of hip pain. Our case highlights the importance of considering TIO when assessing patients with low serum phosphate.Tumour induced osteomalacia(TIO) is a rare and often unrecognized cause of hypophosphatemia. We report on a case of TIO due to a hemangiopericytoma originating from the left nasal sinus. The patient was a 55-year-old male with a 3-year history of left hip pain and an undisplaced left hip fracture. Biochemical testing demonstrated low levels of serum phosphate and serum 1,25-dihydroxyvitamin D, and an elevated level of fibroblast growth factor 23. Octreotide scanning demonstrated uptake in the left nasal sinus area and a computed tomography scan revealed a left nasal sinus mass. The patient underwent surgical resection of the mass and histology was consistent with a sinonasal hemangiopericytoma. His serum phosphate levels normalized almost immediately after surgery and he had complete resolution of hip pain. Our case highlights the importance of considering TIO when assessing patients with low serum phosphate.

关 键 词：PHOSPHATE OSTEOMALACIA TUMOUR FIBROBLAST growth factor 23 

分 类 号：R730.6[医药卫生—肿瘤]