Use of hypothermia in the intensive care unit  

作　　者：Jesse J Corry 

机构地区：[1]Department of Neurology, Marshfield Clinic Marshfield,WI 54449-5777, United States

出　　处：《World Journal of Critical Care Medicine》2012年第4期106-122,共17页世界重症医学杂志

摘　　要：Used for over 3600 years, hypothermia, or targeted temperature management(TTM), remains an ill defined medical therapy. Currently, the strongest evidence for TTM in adults are for out-of-hospital ventricular tachycardia/ventricular fibrillation cardiac arrest, intracerebral pressure control, and normothermia in the neurocritical care population. Even in these disease processes, a number of questions exist. Data on disease specific therapeutic markers, therapeutic depth and duration, and prognostication are limited. Despite ample experimental data, clinical evidence for stroke, refractory status epilepticus, hepatic encephalopathy, and intensive care unit is only at the safety and proof-of-concept stage. This review explores the deleterious nature of fever, the theoretical role of TTM in the critically ill, and summarizes the clinical evidence for TTM in adults.Used for over 3600 years, hypothermia, or targeted temperature management(TTM), remains an ill defined medical therapy. Currently, the strongest evidence for TTM in adults are for out-of-hospital ventricular tachycardia/ventricular fibrillation cardiac arrest, intracerebral pressure control, and normothermia in the neurocritical care population. Even in these disease processes, a number of questions exist. Data on disease specific therapeutic markers, therapeutic depth and duration, and prognostication are limited. Despite ample experimental data, clinical evidence for stroke, refractory status epilepticus, hepatic encephalopathy, and intensive care unit is only at the safety and proof-of-concept stage. This review explores the deleterious nature of fever, the theoretical role of TTM in the critically ill, and summarizes the clinical evidence for TTM in adults.

关 键 词：TARGETED temperature management THERAPEUTIC HYPOTHERMIA Cardiac ARREST NORMOTHERMIA INTRACEREBRAL pressure Critical care 

分 类 号：R459.7[医药卫生—急诊医学]