Brain-derived neurotrophic factor as a potential biomarker of cognitive recovery in schizophrenia  

作　　者：Rafael Penadés Rosa Catalán Irene López-Vílchez Bárbara Arias Alexandre González-Rodríguez Ana M Galán Cristóbal Gastó 

机构地区：[1]Psychiatry and Psychology, ClinicalInstitute of Neurosciences (ICN), Hospital Clínic, 08036 Barcelona, Spain [2]Departmentof Psychiatry and Psychobiology, University of Barcelona, 08036 Barcelona, Spain [3]Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain [4]Centro Investigación en Red Salud Mental (CIBER-SAM), 28007 Madrid, Spain [5]Hemotherapy and Hemo-stasis, Centre for Biomedical Diagnosis, Hospital Clínic, 08036 Barcelona, Spain [6]Department of Anthropology, Faculty of Biol-ogy and Biomedicine Institute, University of Barcelona, 08036 Barcelona, Spain

出　　处：《World Journal of Psychiatry》2013年第4期93-102,共10页世界精神病学杂志

基　　金：Supported by The grants from the Instituto de Salud Carlos Ⅲ of FIS(PI 11/01958);the Intramural Grant from CIBER-SAM to Penadés R

摘　　要：Brain-derived neurotrophic factor(BDNF) has been proposed as a biomarker of schizophrenia and, more specifically, as a biomarker of cognitive recovery. Evidence collected in this review indicates that BDNF is relevant in the pathophysiology of schizophrenia and could play a role as a marker of clinical response. BDNF has been shown to play a positive role as a marker in antipsychotic treatment, and it has been demonstrated that typical antipsychotics decrease BDNF levels while atypical antipsychotics maintain or increase serum BDNF levels. Furthermore, BDNF levels have been associated with severe cognitive impairments in patients with schizophrenia. Consequently, BDNF has been proposed as a candidate target of strategies to aid the cognitive recovery process. There is some evidence suggesting that BDNF could be mediating neurobiological processes underlying cognitive recovery. Thus, serum BDNF levels seem to be involved in some synaptic plasticity and neurotransmission processes. Additionally, serum BDNF levels significantly increased in schizophrenia subjects after neuroplasticity-based cognitive training. If positive replications of those findings are published in the future then serum BDNF levels could be definitely postulated as a peripheral biomarker for the effects of intensive cognitive training or any sort of cognitive recovery in schizophrenia. All in all, the current consideration of BDNF as a biomarker of cognitive recovery in schizophrenia is promising but still premature.Brain-derived neurotrophic factor(BDNF) has been proposed as a biomarker of schizophrenia and, more specifically, as a biomarker of cognitive recovery. Evidence collected in this review indicates that BDNF is relevant in the pathophysiology of schizophrenia and could play a role as a marker of clinical response. BDNF has been shown to play a positive role as a marker in antipsychotic treatment, and it has been demonstrated that typical antipsychotics decrease BDNF levels while atypical antipsychotics maintain or increase serum BDNF levels. Furthermore, BDNF levels have been associated with severe cognitive impairments in patients with schizophrenia. Consequently, BDNF has been proposed as a candidate target of strategies to aid the cognitive recovery process. There is some evidence suggesting that BDNF could be mediating neurobiological processes underlying cognitive recovery. Thus, serum BDNF levels seem to be involved in some synaptic plasticity and neurotransmission processes. Additionally, serum BDNF levels significantly increased in schizophrenia subjects after neuroplasticity-based cognitive training. If positive replications of those findings are published in the future then serum BDNF levels could be definitely postulated as a peripheral biomarker for the effects of intensive cognitive training or any sort of cognitive recovery in schizophrenia. All in all, the current consideration of BDNF as a biomarker of cognitive recovery in schizophrenia is promising but still premature.

关 键 词：SCHIZOPHRENIA BRAIN-DERIVED NEUROTROPHIC factor COGNITION Biomarkers 

分 类 号：R749.3[医药卫生—神经病学与精神病学]