Brain-derived neurotrophic factor levels in first episode of psychosis:A systematic review  

作　　者：Alba Toll Anna Mané 

机构地区：[1]Institut de Neuropsiquitria i Addiccions,Parc de Salut Mar,08003 Barcelona,Spain [2]Fundació Institut Mar d’Investigacions Médiques,Hospital del Mar,08003 Barcelona,Spain [3]Centro de Investigación Biomédica en Red de Salud Mental,08003 Barcelona,Spain

出　　处：《World Journal of Psychiatry》2015年第1期154-159,共6页世界精神病学杂志

摘　　要：AIM: To systematically review studies measuring peripheric brain-derived neurotrophic factor(BDNF) levels on first-episode psychosis patients and variables related to them.METHODS: A systematic search was made of articles published in the Medline database from 2002 up to June 2014. Included are original studies that report enzyme-linked immunosorbent assay measurement of BDNF levels in serum or plasma in patients with a diagnosis of first episode psychosis(FEP) and age- and gender- matched healthy controls.RESULTS: Of the initially identified 147 articles, only 18 satisfied the inclusion criteria. Of this, 15 found a significant reduction in patients with FEP compared with age- and gender- matched controls. CONCLUSION: Peripheral BDNF levels are generally reduced in FEP patients. There are some factors that may influence BDNF levels that need to be further studied. Furthermore, a future meta-analysis in this topic is needed.AIM: To systematically review studies measuring peripheric brain-derived neurotrophic factor(BDNF) levels on first-episode psychosis patients and variables related to them.METHODS: A systematic search was made of articles published in the Medline database from 2002 up to June 2014. Included are original studies that report enzyme-linked immunosorbent assay measurement of BDNF levels in serum or plasma in patients with a diagnosis of first episode psychosis(FEP) and age- and gender- matched healthy controls.RESULTS: Of the initially identified 147 articles, only 18 satisfied the inclusion criteria. Of this, 15 found a significant reduction in patients with FEP compared with age- and gender- matched controls. CONCLUSION: Peripheral BDNF levels are generally reduced in FEP patients. There are some factors that may influence BDNF levels that need to be further studied. Furthermore, a future meta-analysis in this topic is needed.

关 键 词：BRAIN-DERIVED NEUROTROPHIC FACTOR PSYCHOSIS 

分 类 号：R749[医药卫生—神经病学与精神病学]