Interleukins and interleukin receptors in rheumatoid arthritis: Research, diagnostics and clinical implications  

作　　者：Lili Magyari Dalma Varszegi Erzsebet Kovesdi Patricia Sarlos Bernadett Farago Andras Javorhazy Katalin Sumegi Zsolt Banfai Bela Melegh 

机构地区：[1]Department of Medical Genetics, University of Pecs, 7624 Pecs, Hungary [2]Szentagothai Research Centre, 7624 Pecs, Hungary [3]Department of Dermatology, Venereology and Oncodermatology, University of Pecs, 7624 Pecs, Hungary [4]1st Department of Internal Medicine, University of Pecs, 7623 Pecs, Hungary [5]Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, 1446 Budapest, Hungary [6]Department of Urology, University of Pecs, 7621 Pecs, Hungary

出　　处：《World Journal of Orthopedics》2014年第4期516-536,共21页世界骨科杂志（英文版）

基　　金：Supported by The Grant of the Hungarian Science Foundation,No.OTKA K103983

摘　　要：Rheumatoid arthritis(RA) is an autoimmune disease, resulting in a chronic, systemic inflammatory disorder. It may affect many tissues and organs, but it primarily affects the flexible joints. In clinical practice patient care generates many questions about diagnosis, prognosis, and treatment. It is challenging for health care specialists to keep up to date with the medical literature. This review summarizes the pathogenesis, the polymorphisms of interleukin and interleukin genes and the standard available and possible future immunologictargets for RA treatment. The identification of diseaseassociated interleukin and interleukin receptor genes can provide precious insight into the genetic variations prior to disease onset in order to identify the pathways important for RA pathogenesis. The knowledge of the complex genetic background may prove useful for developing novel therapies and making personalized medicine based on the individual's genetics.Rheumatoid arthritis(RA) is an autoimmune disease, resulting in a chronic, systemic inflammatory disorder. It may affect many tissues and organs, but it primarily affects the flexible joints. In clinical practice patient care generates many questions about diagnosis, prognosis, and treatment. It is challenging for health care specialists to keep up to date with the medical literature. This review summarizes the pathogenesis, the polymorphisms of interleukin and interleukin genes and the standard available and possible future immunologictargets for RA treatment. The identification of diseaseassociated interleukin and interleukin receptor genes can provide precious insight into the genetic variations prior to disease onset in order to identify the pathways important for RA pathogenesis. The knowledge of the complex genetic background may prove useful for developing novel therapies and making personalized medicine based on the individual's genetics.

关 键 词：RHEUMATOID ARTHRITIS INTERLEUKINS Polymorphisms IMMUNOLOGIC targets Therapy 

分 类 号：R593.22[医药卫生—内科学]