Muscle wasting in rheumatoid arthritis:The role of oxidative stress  

作　　者：Antonios Stavropoulos-Kalinoglou Charikleia Deli George D Kitas Athanasios Z Jamurtas 

机构地区：[1]Department of Sport and Exercise Science,University of Thessaly,42100 Trikala,Greece [2]Department of Rheumatology,Dudley Group NHS Foundation Trust,Russell’s Hall Hospital,Dudley,West Midlands DY1 2HQ,United Kingdom [3]Arthritis Research UK Epidemiology Unit,University of Manchester,Manchester M13 9PT,United Kingdom [4]Institute of Human Performance and Rehabilitation,Centre for Research and Technology Thessaly,42100 Trikala,Greece

出　　处：《World Journal of Rheumatology》2014年第3期44-53,共10页世界风湿病学杂志

基　　金：Supported by The research project is implemented within the framework of the Action of the Operational Program "Education and Lifelong Learning"(Action’s Beneficiary:General Secretariat for Research and Technology);cofinanced by the European Social Fund(ESF);the Greek State

摘　　要：Rheumatoid arthritis(RA), the commonest inflammatory arthritis, is a debilitating disease leading to functional and social disability. In addition to the joints, RA affects several other tissues of the body including the muscle. RA patients have significantly less muscle mass compared to the general population. Several theories have been proposed to explain this. High grade inflammation, a central component in the pathophysiology of the disease, has long been proposed as the key driver of muscle wasting. More recent findings however, indicate that inflammation on its own cannot fully explain the high prevalence of muscle wasting in RA. Thus, thecontribution of other potential confounders, such as nutrition and physical activity, has also been studied. Results indicate that they play a significant role in muscle wasting in RA, but again neither of these factors seems to be able to fully explain the condition. Oxidative stress is one of the major mechanisms thought to contribute to the development and progression of RA but its potential contribution to muscle wasting in these patients has received limited attention. Oxidative stress has been shown to promote muscle wasting in healthy populations and people with several chronic conditions. Moreover, all of the aforementioned potential contributors to muscle wasting in RA(i.e., inflammation, nutrition, and physical activity) may promote pro- or antioxidative mechanisms. This review aims to highlight the importance of oxidative stress as a driving mechanism for muscle wasting in RA and discusses potential interventions that may promote muscle regeneration via reduction in oxidative stress.Rheumatoid arthritis(RA), the commonest inflammatory arthritis, is a debilitating disease leading to functional and social disability. In addition to the joints, RA affects several other tissues of the body including the muscle. RA patients have significantly less muscle mass compared to the general population. Several theories have been proposed to explain this. High grade inflammation, a central component in the pathophysiology of the disease, has long been proposed as the key driver of muscle wasting. More recent findings however, indicate that inflammation on its own cannot fully explain the high prevalence of muscle wasting in RA. Thus, thecontribution of other potential confounders, such as nutrition and physical activity, has also been studied. Results indicate that they play a significant role in muscle wasting in RA, but again neither of these factors seems to be able to fully explain the condition. Oxidative stress is one of the major mechanisms thought to contribute to the development and progression of RA but its potential contribution to muscle wasting in these patients has received limited attention. Oxidative stress has been shown to promote muscle wasting in healthy populations and people with several chronic conditions. Moreover, all of the aforementioned potential contributors to muscle wasting in RA(i.e., inflammation, nutrition, and physical activity) may promote pro- or antioxidative mechanisms. This review aims to highlight the importance of oxidative stress as a driving mechanism for muscle wasting in RA and discusses potential interventions that may promote muscle regeneration via reduction in oxidative stress.

关 键 词：RHEUMATOID ARTHRITIS OXIDATIVE stress Muscle WASTING Inflammation CYTOKINES Exercise 

分 类 号：R[医药卫生]