Disciplined sleep for healthy living: Role of noradrenaline  

作　　者：Rachna Mehta Abhishek Singh Birendra Nath Mallick 

机构地区：[1]School of Life Sciences, Jawaharlal Nehru University

出　　处：《World Journal of Neurology》2017年第1期6-23,共18页世界神经病学杂志

基　　金：Rachna Mehta received DST-WOSA fellowship;Abhishek Singh received UGC senior research fellowship;Research funding to BNM through Institutional support under BUILDER (DBT);PURSE (DST);FIST (DST);UPE, Networking and SAP-DRS (UGC);grants to BNM from UGC, DBT, DST;J C Bose fellowship are acknowledged

摘　　要：Sleep is essential for maintaining normal physiological processes. It has been broadly divided into rapid eye movement sleep(REMS) and non-REMS(NREMS); one spends the least amount of time in REMS. Sleep(both NREMS and REMS) disturbance is associated with most altered states, disorders and pathological conditions. It is affected by factors within the body as well as the environment, which ultimately modulate lifestyle.Noradrenaline(NA) is one of the key molecules whose level increases upon sleep-loss, REMS-loss in particular and it induces several REMS-loss associated effects and symptoms. The locus coeruleus(LC)-NAergic neurons are primarily responsible for providing NA throughout the brain. As those neurons project to and receive inputs from across the brain, they are modulated by lifestyle changes, which include changes within the body as well as in the environment. We have reviewed the literature showing how various inputs from outside and within the body integrate at the LC neuronal level to modulate sleep(NREMS and REMS) and vice versa. We propose that these changes modulate NA levels in the brain, which in turn is responsible for acute as well as chronic psychosomatic disorders and pathological conditions.Sleep is essential for maintaining normal physiological processes. It has been broadly divided into rapid eye movement sleep(REMS) and non-REMS(NREMS); one spends the least amount of time in REMS. Sleep(both NREMS and REMS) disturbance is associated with most altered states, disorders and pathological conditions. It is affected by factors within the body as well as the environment, which ultimately modulate lifestyle.Noradrenaline(NA) is one of the key molecules whose level increases upon sleep-loss, REMS-loss in particular and it induces several REMS-loss associated effects and symptoms. The locus coeruleus(LC)-NAergic neurons are primarily responsible for providing NA throughout the brain. As those neurons project to and receive inputs from across the brain, they are modulated by lifestyle changes, which include changes within the body as well as in the environment. We have reviewed the literature showing how various inputs from outside and within the body integrate at the LC neuronal level to modulate sleep(NREMS and REMS) and vice versa. We propose that these changes modulate NA levels in the brain, which in turn is responsible for acute as well as chronic psychosomatic disorders and pathological conditions.

关 键 词：EPIGENETIC changes Healthy living LIFESTYLE NORADRENALINE SLEEP disturbance Psycho-somatic and METABOLOMIC disorders 

分 类 号：R[医药卫生]