乳酸菌Ⅱ类细菌素生物合成及其代谢调控策略  

Biosynthesis and strategies of metabolism regulation for class Ⅱ bacteriocins produced by lactic acid bacteria

作　　者：章检明 张兰威 易华西[2] 韩雪[1] ZHANG Jianming;ZHANG Lanwei;YI Huaxi;HAN Xue(School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150000, China;Institute of Food Science and Engineering, Ocean University of China, Qingdao 266000, China)

机构地区：[1]哈尔滨工业大学化工与化学学院,黑龙江哈尔滨150000 [2]中国海洋大学食品科学与工程学院,山东青岛266000

出　　处：《中国酿造》2019年第2期1-6,共6页China Brewing

基　　金：国家自然基金项目(31771988;31571850;31271906/C200204);哈尔滨市优秀学科带头人基金(RC2014XK020003);高等学校博士学科点专项科研基金(20112302110051);中国海洋大学"青年英才工程"项目(201712002)

摘　　要：乳酸菌细菌素是乳酸菌经由核糖体合成的具有抑菌活性的多肽类物质,其中乳酸菌Ⅱ类细菌素具有很强的热稳定性和抑菌活性,但是产量较低尚不能实现商业化生产。因此,了解和掌握乳酸菌Ⅱ类细菌素合成及其代谢调控机制,对解决商业化生产过程的技术瓶颈具有重要的意义。该文综述了目前Ⅱ类细菌素生物合成和降解途径,并从代谢调控角度提出提高Ⅱ类细菌素产量的可行性策略,为提高Ⅱ类细菌素产量提供新的途径和思路,也为Ⅱ类细菌素工业化生产奠定基础。Bacteriocins of lactic acid bacteria are peptides with antimicrobial activity synthesized by ribosome of lactic acid bacteria. Class II bacteriocins produced by lactic acid bacteria had strong heat stability and antimicrobial activity, but the yield was too low to realize commercial production. Therefore, understanding the synthesis and metabolic regulation mechanism of class Ⅱ bacteriocins produced by lactic acid bacteria has great importance to the technical bottleneck of commercial production. The biosynthesis and degradation pathway for class Ⅱ bacteriocins were reviewed, some feasible strategies to increase bacteriocins production were proposed. So, the paper provided a new way for increasing bacteriocins production and a certain basis for industrial production of class Ⅱ bacteriocins.

关 键 词：乳酸菌 Ⅱ类细菌素 生物合成 代谢调控 策略 

分 类 号：TS201.3[轻工技术与工程—食品科学]