Agnuside Reduces Visceral Adipocyte Size,Improves Insulin Sensitivity and Reverses Hepatic Steatosis in Ovariectomized Rats  

作　　者：Franciele Neves Moreno Eduardo Hideo Gilglioni Rosangela Fernandes Garcia Naiara Cristina Lucredi Sandra Mara Ferreira Nilton Almeida Brito Marcia do Nascimento Brito Emy Luiza Ishii-Iwamoto Clairce Luzia Salgueiro-Pagadigorria 

机构地区：[1]Laboratory of Experimental Steatosis,Department of Biochemistry,State University of Maringa,Maringa 87020-900,PR,Brazil [2]Laboratory of Biological Oxidations,Department of Biochemistry,State University of Maringa,Maringa 87020-900,PR,Brazil [3]Department of Physiological Sciences,State University of Maringa,Maringa 87020-900,PR,Brazil [4]Laboratory of Biological oxidations,Department of Biochemistry,Federal University of Santa Catarina,Florianopolis 88040-900,SC,Brazil [5]Department of Structural and Functional Biology,Institute of Biology,State University of Campinas(UNICAMP),Campinas 13083-970,SP,Brazil

出　　处：《Journal of Pharmacy and Pharmacology》2019年第4期133-147,共15页药剂与药理学（英文版）

摘　　要：This study aimed to investigate the effects of agnuside(AGN),a phytoestrogen in Vitex agnus-castus,on cellular and metabolic alterations induced by ovariectomy in rats.Ovariectomized(OVX)Wistar rats were used as an animal model of postmenopausal metabolic syndrome.The visceral and subcutaneous adipocyte sizes,the peripheral insulin sensitivity and the occurrence of nonalcoholic fatty liver disease(NAFLD)and liver oxidative damage were evaluated.The results were compared with those obtained from control rats(sham-operated)and OVX rats treated daily with AGN.Obese OVX rats exhibited visceral adipocyte hypertrophy and developed glucose intolerance,hyperinsulinemia,NAFLD and dyslipidemia.AGN exerted beneficial effects on several metabolic parameters in OVX rats,including the improvement in glucose intolerance,hyperinsulinemia and NAFLD.Besides,AGN promoted a general improvement in the liver redox state.Although the reduction of the mesenteric adipocyte size is very likely to be an important mode of action of AGN,some actions of AGN could also involve the interaction with estrogen receptors.

关 键 词：METABOLIC syndrome OVARIECTOMIZED rats ADIPOCYTE size NAFLD agnuside 

分 类 号：R[医药卫生]