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作 者:Guo-Wen Lin Gao-Xiang Li Bo Dai Ding-Wei Ye Yun-Yi Kong Yue Wang Yi-Jun Shen
机构地区:[1]Department of Urology,Fudan University Shanghai Cancer Center,Shanghai 20032,China [2]Department of Oncology,Fudan University Shanghai Medical College,Shanghai 200032,China [3]Department of Pathology,Fudan University Shanghai Cancer Center,Shanghai 200032,China
出 处:《Asian Journal of Andrology》2019年第2期131-136,共6页亚洲男性学杂志(英文版)
基 金:the National Natural Science Foundation(No.81702535,81572531);Natural Science Foundation of Shanghai Municipality(No.16ZR1406500);Outstanding Young Talent Training Plan of Shanghai Municipal Commission of Health and Family Planning(No.XYQ2013102).
摘 要:This study investigated the clinical activity of abiraterone plus prednisone in docetaxel-naive and docetaxel-resistant Chinese patients with metastatic castratio n-resista nt prostate can cer(mCRPC).A total of 146 patie nts with docetaxel-naive group(103 cases)and docetaxel-resista nt group(43 cases)were en rolled from the Sha nghai Cancer Center(Sha nghai,Chin a)in this retrospective cohort study.The efficacy endpoints were prostate-specific antigen response rate,prostate-specific antigen progress!on-free survival,clinical/radiographic progression-free survival,and overall survival in response to abiraterone plus prednisone.Significantly higher prostate-specific antigen response rate was found in docetaxel-naive group(54.4%,56/103)compared to docetaxel-resistant group(34.9%,15/43)(P=0.047).In addition,significantly higher median prostate-specific antigen progress!on-free survival(14.0 vs 7.7 months,P=0.005),clinical or radiographic progression-free survival(17.0 vs 12.5 months,P=0.003),and overall survival(27.0 vs 18.0 mon ths,P=0.016)were found in docetaxel-naTve group compared to docetaxel-resistant group,respectively.The univariate and multivariate analyses indicated that lower albumin and visceral metastases were independent significant predictors for shorter overall survival.To sum up,our data suggested that abiraterone plus prednisone was efficient in both docetaxel-naTve and docetaxel-resistant Chinese patients.Moreover,higher PSA response rate and longer overall survival were observed in the docetaxel-naTve group,which suggested that abiraterone was more effective for docetaxel-naive patients than for docetaxel failures.
关 键 词:ABIRATERONE ACETATE CASTRATION-RESISTANT prostate cancer clinical activity docetaxel-naive docetaxel-pretreated
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