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CASTRATION-RESISTANT: 作品数：17被引量：48H指数：4; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：李琦更多>>; 相关机构：中国中医科学院西苑医院更多>>; 相关期刊：《Science China(Life Sciences)》《Precision Clinical Medicine》《World Journal of Methodology》《World Journal of Clinical Oncology》更多>>; 相关基金：国家自然科学基金天津市自然科学基金上海市自然科学基金中国博士后科学基金更多>>

Radiotherapy of Oligoprogressive Lesions in Castration-Resistant Prostate Cancer: Impact on Second-Generation Hormone Therapy: 《Journal of Cancer Therapy》2021年第5期302-310,共9页Kanta Ka Papa Macoumba Gaye Awa Sadikh Badiane Ibrahima Thiam Mouhamadou Bachir Ba Papa Massamba Diene Maimouna Mané Lamine Niang Fatou Samba Ndiaye; Background: The therapeutic standard for oligoprogressive prostate cancer resistant to castration is second-generation hormone therapy. T...; 关键词：Ablative Radiotherapy Hormone Therapy Oligometastasis PROSTATE Castration-Resistant Cancer

Upregulation of erythropoietin and erythropoietin receptor in castration-resistant progression of prostate cancer被引量：1: 《Asian Journal of Andrology》2020年第4期422-426,共5页Chen Ye Guang-Hua Chen Xin Chen Sheng-Fei Qin Min-Feng Shi Tie Zhou; the National Natural Science Foundation of China(No.81070602);China Postdoctoral Science Foundation(No.43655);Changhai Hospital GCP platform(No.2017ZX09304030).; Hypoxia-induced erythropoietin signaling plays an important role in tumor growth and invasion.In the present study,we investigated the contribution of erythropoietin signaling pathway to castration-resistant prostate ...; 关键词：ERYTHROPOIETIN erythropoietin receptor HYPOXIA prostatic neoplasm

Androgen receptor mediated resistance in the progression of castration-resistant prostate cancer: 《TMR Integrative Medicine》2019年第23期1-11,共11页Rui-Yu Mou Xiao-Jiang Li Shan-Qi Guo Wen-Jie Li Ming-Xin Wu Xiao-Di Liu Zhang Chang Song Bo Chang Zhang Ying-Jie Jia; This study was funded by the National Natural Science Foundation of China (81603438), the Natural Science Foundation of Tianjin (19JCZDJC37000).; The incidence of prostate cancer has increased year by year in the world.Despite improvements in diagnosis,surgical techniques,and drugs,survival rates of prostate cancer have improved little,and most prostate cancer-...; 关键词：CASTRATION-RESISTANT PROSTATE CANCER ANDROGEN RECEPTOR MiRNA Mechanism study

Fatty acid-binding protein 5(FABP5)-related signal transduction pathway in castration-resistant prostate cancer cells:a potential therapeutic target: 《Precision Clinical Medicine》2019年第3期192-196,共5页Abdulghani ANaeem Saud A.Abdulsamad Philip S.Rudland Mohammed IMalki Youqiang Ke; In this short communication,a novel fatty acid-binding protein 5(FABP5)-related signal transduction pathway in prostate cancer is reviewed.In castration-resistant prostate cancer(CRPC)cells,the FABP5-related signal tr...; 关键词：FABP5 CRPC fatty acids PPARΓ tumorigenicity METASTASIS

Forkhead domain mutations in FOXA1 drive prostate cancer progression被引量：3: 《Cell Research》2019年第9期770-772,共3页Shuai Gao Sujun Chen Dong Han David Barrett Wanting Han Musaddeque Ahmed Susan Patalano Jill A. Macoska Housheng Hansen He Changmeng Cai; Dear Editor,F0XA1 (Forkhead Box Protein A1)is a pioneer transcription factor (TF) that functions to loosen the compact chromatin structure to facilitate binding of other TFs such as estrogen receptor and androgen rece...; 关键词：FOXA1 CASTRATION-RESISTANT Pca (CRPC) PROSTATE cancer (Pca)

The regulatory pathways leading to stem-like cells underlie prostate cancer progression被引量：6: 《Asian Journal of Andrology》2019年第3期233-240,共8页Chun-Jung Lin U-Ging Lo Jer-Tsong Hsieh; Prostate cancer (PCa) is the most common cause of malignancy in males and the third leading cause of cancer mortality in the United States. The standard care for primary PCa with local invasive disease mainly is surge...; 关键词：CANCER STEM cell CASTRATION-RESISTANT prostate CANCER NEUROENDOCRINE differentiation TRANSDIFFERENTIATION

Enzalutamide:a new indication for nonmetastatic castration-resistant prostate cancer: 《Asian Journal of Andrology》2019年第2期107-108,共2页Logan P Rhea Brinda Gupta Jeanny B Aragon-Ching; PROSPER is an international Phase III trial demonstrating the beneficial role of enzalutamide,an androgen receptor antagonist,in prolonging metastasisfree survival in men with nonmetastatic castration-resistant prosta...; 关键词：PROSPER beneficial ROLE NONMETASTATIC CASTRATION-RESISTANT PROSTATE CANCER

Clinical activity of abiraterone plus prednisone in docetaxel-naive and docetaxel-resistant Chinese patients with metastatic castration-resistant prostate cancer被引量：2: 《Asian Journal of Andrology》2019年第2期131-136,共6页Guo-Wen Lin Gao-Xiang Li Bo Dai Ding-Wei Ye Yun-Yi Kong Yue Wang Yi-Jun Shen; the National Natural Science Foundation(No.81702535,81572531);Natural Science Foundation of Shanghai Municipality(No.16ZR1406500);Outstanding Young Talent Training Plan of Shanghai Municipal Commission of Health and Family Planning(No.XYQ2013102).; This study investigated the clinical activity of abiraterone plus prednisone in docetaxel-naive and docetaxel-resistant Chinese patients with metastatic castratio n-resista nt prostate can cer(mCRPC).A total of 146 pa...; 关键词：ABIRATERONE ACETATE CASTRATION-RESISTANT prostate cancer clinical activity docetaxel-naive docetaxel-pretreated

Regulatory effects of antitumor agent matrine on FOXO and PI3K-AKT pathway in castration-resistant prostate cancer cells被引量：13: 《Science China(Life Sciences)》2018年第5期550-558,共9页Qi Li HaiH uang Zheng He Yi Sun Yufeng Tang Xiaohong Shang Chengbin Wang; supported by the National Natural Science Foundation of China (81472382);the National Natural Science Foundation of China for Young Scientists (81101947);the Guangdong Province Natural Science Foundation (2014A030313079);the Fundamental Research Funds for the Central Universities (14ykpy19);Guangdong Province Science and Technology for Social Development Project (2013B021800107);Guangzhou City in 2015 scientific research projects (7415600066401 to Hai Huang); We previously demonstrated that matrine could inhibit the proliferating, migrating, as well as invading processes of both PC-3 and DU145 cells. However, the underlying molecular mechanisms have not yet been clearly de...; 关键词：matrine androgen-independent prostate cancer mRNA FOXO signaling pathway PI3K-AKT signaling pathway

External validation and newly development of a nomogram to predict overall survival of abiraterone-treated, castration-resistant patients with metastatic prostate cancer被引量：1: 《Asian Journal of Andrology》2018年第2期184-188,共5页Yun-Jie Yang Guo-Wen Lin Gao-Xiang Li Bo Dai Ding-Wei Ye Jun-Long Wu Hu-Yang Xie Yao Zhu; Abiraterone acetate is approved for the treatment of castration-resistant prostate cancer （CRPC）; however, its effects vary. An accurate prediction model to identify patient groups that will benefit from abiraterone...; 关键词：abiraterone acetate castration-resistant prostate cancer external validation NOMOGRAM surviva

CASTRATION-RESISTANT