Androgen receptor mediated resistance in the progression of castration-resistant prostate cancer  

作　　者：Rui-Yu Mou Xiao-Jiang Li Shan-Qi Guo Wen-Jie Li Ming-Xin Wu Xiao-Di Liu Zhang Chang Song Bo Chang Zhang Ying-Jie Jia 

机构地区：[1]First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193 China

出　　处：《TMR Integrative Medicine》2019年第23期1-11,共11页TMR整合医学

基　　金：This study was funded by the National Natural Science Foundation of China (81603438), the Natural Science Foundation of Tianjin (19JCZDJC37000).

摘　　要：The incidence of prostate cancer has increased year by year in the world.Despite improvements in diagnosis,surgical techniques,and drugs,survival rates of prostate cancer have improved little,and most prostate cancer-related deaths are as a result of castration resistant prostate cancer(CRPC),which progresses and metastasizes after surgical or medical castration.The pathogenesis of CRPC is still unclear.It has been found that the majority of CRPC patients have overexpression of androgen receptors(ARs),and there are many forms of changes in the signaling pathways that intersect with them during he process to CRPC.Micro ribonucleic acid(miRNA)plays an important role in regulating the expression and translation of prostate cancer target genes,and in the life cycle of cell cycle distribution and apoptosis.Relatedly,active changes in miRNA expression are also closely related to androgen.Therefore,the study of AR-related signaling pathways and AR and miRNA-related signaling pathways is of great significance in the treatment of CRPC.

关 键 词：CASTRATION-RESISTANT PROSTATE CANCER ANDROGEN RECEPTOR MiRNA Mechanism study 

分 类 号：R73[医药卫生—肿瘤]