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作 者:Alex Perchuk Sonya M.Bierbower Ana Canseco-Alba Zoila Mora Lauren Tyrell Neal Joshi Norman Schanz Georgianna G.Gould Emmanuel S.Onaivi
机构地区:[1]Department of Biology,Willam Paterson UniversityWayne,NJ 07403,USA [2]Center for Biomedical Neuroscience,University of Texas Health Science Center at San AntonioSan Antonio,TX78229,USA
出 处:《Acta Pharmacologica Sinica》2019年第3期418-424,共7页中国药理学报(英文版)
摘 要:Despite the apparent abundance of ligand-gated transient receptor potential vanilloid type 1(TRPV1)and possible cross talk between the endocannabinoid and endovanilloid systems in the central nervous system(CNS),it is unclear what role TRPV1 receptor activation in CNS plays in neurobehavioral development.We previously reported that capsaicin or WIN55212-2 induces risk aversion in the plus-maze test,which was dependent on the gender andmouse strain used.In this study,pregnant BALBc mice were administered capsaicin(1.0 or 4.0mg/kg,i.p.)during the second week of gestation.Developmental effects of prenatal exposure to capsaicin were assessed in neonates,and behavioral effects were assessed in adult offspring.Gender-and dose-specific variations in ultrasonic vocalizations,weight gain,righting reflex,and general activity of the pups were observed.Prenatal exposure to capsaicin altered plus-maze performance,especially with further exogenous capsaicin challenge.Furthermore,dose-and gender-specific effects were evident in the conditioned place preference/aversion paradigm following conditioning with capsaicin in adult animals.The capsaicin-induced aversion in the plus-maze test was enhanced by WIN55212-2 and blocked by pretreatment with vanilloid antagonist capsazepine or the CB1 receptor antagonist rimonabant,demonstrating an interaction between the endocannabinoid and endovanilloid systems in CNS.Taken together,the interaction between the endocannabinoid and endovanilloid signaling systems can be exploited for therapeutic applications in health and disease.
关 键 词:vanilloids CANNABINOIDS conditioned place preference PRENATAL exposure plus-maze REWARD CAPSAICIN WIN55212-2 CAPSAZEPINE RIMONABANT
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