Long non-coding RNA: The functional regulator of mesenchymal stem cells  

作　　者：Zhong-Yu Xie Peng Wang Yan-Feng Wu Hui-Yong Shen 

机构地区：[1]Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University [2]Center for Biotherapy, Sun Yat-sen Memorial Hospital, Sun Yat-sen University

出　　处：《World Journal of Stem Cells》2019年第3期167-179,共13页世界干细胞杂志（英文版）（电子版）

基　　金：the National Natural Science Foundation of China,Nos.81672097,81672128,and 81702120

摘　　要：Mesenchymal stem cells(MSCs) are a subset of multipotent stroma cells residing in various tissues of the body. Apart from supporting the hematopoietic stem cell niche, MSCs possess strong immunoregulatory ability and multiple differentiation potentials. These powerful capacities allow the extensive application of MSCs in clinical practice as an effective treatment for diseases.Therefore, illuminating the functional mechanism of MSCs will help to improve their curative effect and promote their clinical use. Long noncoding RNA(LncRNA) is a novel class of noncoding RNA longer than 200 nt. Recently,multiple studies have demonstrated that LncRNA is widely involved in growth and development through controlling the fate of cells, including MSCs. In this review, we highlight the role of LncRNA in regulating the functions of MSCs and discuss their participation in the pathogenesis of diseases and clinical use in diagnosis and treatment.Mesenchymal stem cells(MSCs) are a subset of multipotent stroma cells residing in various tissues of the body. Apart from supporting the hematopoietic stem cell niche, MSCs possess strong immunoregulatory ability and multiple differentiation potentials. These powerful capacities allow the extensive application of MSCs in clinical practice as an effective treatment for diseases.Therefore, illuminating the functional mechanism of MSCs will help to improve their curative effect and promote their clinical use. Long noncoding RNA(LncRNA) is a novel class of noncoding RNA longer than 200 nt. Recently,multiple studies have demonstrated that LncRNA is widely involved in growth and development through controlling the fate of cells, including MSCs. In this review, we highlight the role of LncRNA in regulating the functions of MSCs and discuss their participation in the pathogenesis of diseases and clinical use in diagnosis and treatment.

关 键 词：MESENCHYMAL stem CELLS Long NON-CODING RNA REGULATOR MULTIPOTENT stroma CELLS 

分 类 号：R[医药卫生]