Tandem pore TWIK-related potassium channels and neuroprotection  

作　　者：J.Antonio Lamas Diego Fernández-Fernández 

机构地区：[1]Laboratory of Neuroscience, Biomedical Research Center (CINBIO), University of Vigo

出　　处：《Neural Regeneration Research》2019年第8期1293-1308,共16页中国神经再生研究（英文版）

基　　金：supported by grants to JAL from the Spanish Government:Secretaría de Estado de Investigación,Desarrollo e Innovación(MINECO,BFU2014-58999-P),Galician Government:Consellería de Cultura,Educación e Ordenación Universitaria,Xunta de Galicia(GPC2015/022);European Regional Development Fund(FP7-316265-BIOCAPS);supported with Fondo Europeo de Desarrollo Regional Funds

摘　　要：TWIK-related potassium channels (TREK) belong to a subfamily of the two-pore domain potassium channels family with three members, TREK1, TREK2 and TWIK-related arachidonic acid-activated potassium channels. The two-pore domain potassium channels is the last big family of channels being discovered, therefore it is not surprising that most of the information we know about TREK channels predominantly comes from the study of heterologously expressed channels. Notw让hstanding, in this review we pay special attention to the limited amount of information available on native TREK-like channels and real neurons in relation to neuroprotection. Mainly we focus on the role of free fatty acids, lysophospholipids and other neuroprotective agents like riluzole in the modulation of TREK channels, emphasizing on how important this modulation may be for the development of new therapies against neuropathic pain, depression, schizophrenia, epilepsy, ischemia and cardiac complications.TWIK-related potassium channels(TREK) belong to a subfamily of the two-pore domain potassium channels family with three members, TREK1, TREK2 and TWIK-related arachidonic acid-activated potassium channels. The two-pore domain potassium channels is the last big family of channels being discovered, therefore it is not surprising that most of the information we know about TREK channels predominantly comes from the study of heterologously expressed channels. Notwithstanding, in this review we pay special attention to the limited amount of information available on native TREK-like channels and real neurons in relation to neuroprotection. Mainly we focus on the role of free fatty acids, lysophospholipids and other neuroprotective agents like riluzole in the modulation of TREK channels, emphasizing on how important this modulation may be for the development of new therapies against neuropathic pain, depression, schizophrenia, epilepsy, ischemia and cardiac complications.

关 键 词：TREK channels TREK-1 TREK-2 TRAAK NEUROPROTECTION free FATTY acids LYSOPHOSPHOLIPIDS RILUZOLE 

分 类 号：R[医药卫生]