RNA-seq analysis of molecular heterogeneity peripheral blood mononuclear cells in systemic lupus erythematosus  

作　　者：Ke Xue Ya-Jie Zheng Rui-Xing Yu Xue Shen Yong Cui 

机构地区：[1]Department of Dermatology,China-Japan Friendship Hospital,Beijing 100029,China [2]Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China [3]Institute of Dermatology and Department of Dermatology,the First Affiliated Hospital,Anhui Medical University,Anhui,Hefei 230022,China

出　　处：《Chinese Medical Journal》2019年第7期842-845,共4页中华医学杂志（英文版）

基　　金：the National Key Research Program of China(No.2016YFC0906102);the National Nature Science Foundation of China(No.81573033).

摘　　要：Systemic lupus erythematosus(SLE)is an autoimmune disease characterized by a broad spectrum of clinical manifestations.Although great progress has been made in understanding the contribution of genetic and environmental factors in SLE pathogenesis,as there are over 20,000 published studies evaluating related cellular dysfunction,111 the exact mechanisms that underline this process are still unknown.Over the past 10 years,novel insights have mainly originated from genome-wide association(GWAS)and gene expression studies.

关 键 词：SYSTEMIC LUPUS erythematosus(SLE) clinical MANIFESTATIONS SLE PATHOGENESIS 

分 类 号：R[医药卫生]