Research Progress on Biological Activity of Cytisine  

作　　者：Hongxing WANG Hui XUE Tong ZHANG Shinong WANG Yinghua LUO Chenghao JIN 

机构地区：[1]College of Life Science and Technology,Heilongjiang Bayi Agricultural University

出　　处：《Medicinal Plant》2019年第2期1-2,5,共3页药用植物：英文版

基　　金：Supported by the Multigrain Production and Processing Characteristic Discipline Construction Project;the Postdoctoral Scientific Research Foundation of Heilongjiang Province of China(LBH-Q13132);the National Key Research and Development Plan(2017YFD0401203)

摘　　要：Cytisine(Cyt) is a kind of quinolizidine alkaloids mainly existing in seeds of plants from Laburnum of Leguminosae sp. In recent years, various biological activities of Cyt have been explored gradually, and it has the effects of quitting smoking, promoting breathing, analgesia, and anti-cancer. At anti-cancer aspect, Cyt could induce apoptosis of cancer cells, and has been widely applied to inhibit proliferation of multiple tumor cells. At quitting smoking aspect, Cyt could be taken as selective local agonist to decline smokers' dependence on nicotine, and it is expected to be widely used in quitting smoking. At analgesia aspect, Cyt could regulate reflective exciting breathing and has been widely used in anesthesia of patients in clinical operation. In this paper, through consulting and verifying a large number of documents, biological activities of Cyt and its related action mechanisms are summarized, to provide theoretic basis for the development and utilization of Cyt.Cytisine(Cyt) is a kind of quinolizidine alkaloids mainly existing in seeds of plants from Laburnum of Leguminosae sp. In recent years, various biological activities of Cyt have been explored gradually, and it has the effects of quitting smoking, promoting breathing, analgesia, and anti-cancer. At anti-cancer aspect, Cyt could induce apoptosis of cancer cells, and has been widely applied to inhibit proliferation of multiple tumor cells. At quitting smoking aspect, Cyt could be taken as selective local agonist to decline smokers' dependence on nicotine, and it is expected to be widely used in quitting smoking. At analgesia aspect, Cyt could regulate reflective exciting breathing and has been widely used in anesthesia of patients in clinical operation. In this paper, through consulting and verifying a large number of documents, biological activities of Cyt and its related action mechanisms are summarized, to provide theoretic basis for the development and utilization of Cyt.

关 键 词：CYTISINE ANTI-CANCER QUITTING SMOKING BIOLOGICAL ACTIVITY 

分 类 号：R[医药卫生]