Tubulin glutamylation: a skeleton key for neurodegenerative diseases  

作　　者：Siem van der Laan Geronimo Dubra Krzysztof Rogowski 

机构地区：[1]Institute of Human Genetics (IGH), Tubulin Code Team, Centre National de la Recherche Scientifique (CNRS)-University of Montpellier

出　　处：《Neural Regeneration Research》2019年第11期1899-1900,共2页中国神经再生研究（英文版）

基　　金：supported by ANR-13-JSV2-0002,Centre d’Excellence en maladies Neuro-dégénératives(CoEN)de Montpellier and France Alzheimer

摘　　要：Microtubules (MTs) are cytoskeletal elements formed by a non-covalent association of α- and β-tubulin heterodimers. They provide structure and shape to all eukaryotic cells and are implicated in a variety of fundamental cellular processes including cell motility, cell division, mechanotransduction as well as long-distance intracellular cargo transport. In neurons, they constitute the molecular frame that maintains the lengthy axonal projections. In view of the relative size of some axons in the human body, which can reach up to 1 m, the active transport of e.g., vesicles over the MT arrays to the synaptic cleft, is of particular importance.

关 键 词：NEURODEGENERATIVE DISEASES Microtubules(MTs) cellular processes 

分 类 号：R[医药卫生]