More than anti-malarial agents: therapeutic potential of artemisinins in neurodegeneration  

作　　者：Bing-Wen Lu Larry Baum Kwok-Fai So Kin Chiu Li-Ke Xie 

机构地区：[1]Department of Ophthalmology,Eye Hospital,China Academy of Chinese Medical Sciences,Beijing,China [2]Department of Ophthalmology,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administration Region,China [3]State Key Laboratory of Brain and Cognitive Sciences,The University of Hong Kong,Hong Kong Special Administration Region,China [4]Center for Genomic Sciences,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Li Ka Shing Faculty of Medicine,Hong Kong Special Administration Region,China [5]Department of Psychiatry,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Li Ka Shing Faculty of Medicine,Hong Kong Special Administration Region,China [6]GHM Institute of CNS Regeneration,Jinan University,Guangzhou,Guangdong Province,China Funding:This

出　　处：《Neural Regeneration Research》2019年第9期1494-1498,共5页中国神经再生研究（英文版）

基　　金：supported by the Natural Science Foundation of Beijing of China,No.7192235(to LKX)

摘　　要：Artemisinin,also called qinghaosu,is originally derived from the sweet wormwood plant(Artemisia annua),which is used in traditional Chinese medicine.Artemisinin and its derivatives(artemisinins)have been widely used for many years as anti-malarial agents,with few adverse side effects.Interestingly,evidence has recently shown that artemisinins might have a therapeutic value for several other diseases beyond malaria,including cancers,inflammatory diseases,and autoimmune disorders.Neurodegeneration is a challenging age-associated neurological disorder characterized by deterioration of neuronal structures as well as functions,whereas neuroinflammation has been considered to be an underlying factor in the development of various neurodegenerative disorders,including Alzheimer’s disease.Recently discovered properties of artemisinins suggested that they might be used to treat neurodegenerative disorders by decreasing oxidation,inflammation,and amyloid beta protein(Aβ).In this review,we will introduce artemisinins and highlight the possible mechanisms of their neuroprotective activities,suggesting that artemisinins might have therapeutic potential in neurodegenerative disorders.Artemisinin, also called qinghaosu, is originally derived from the sweet wormwood plant(Artemisia annua),which is used in traditional Chinese medicine. Artemisinin and its derivatives(artemisinins) have been widely used for many years as anti-malarial agents, with few adverse side effects. Interestingly, evidence has recently shown that artemisinins might have a therapeutic value for several other diseases beyond malaria,including cancers, inflammatory diseases, and autoimmune disorders. Neurodegeneration is a challenging age-associated neurological disorder characterized by deterioration of neuronal structures as well as functions, whereas neuroinflammation has been considered to be an underlying factor in the development of various neurodegenerative disorders, including Alzheimer’s disease. Recently discovered properties of artemisinins suggested that they might be used to treat neurodegenerative disorders by decreasing oxidation,inflammation, and amyloid beta protein(Aβ). In this review, we will introduce artemisinins and highlight the possible mechanisms of their neuroprotective activities, suggesting that artemisinins might have therapeutic potential in neurodegenerative disorders.

关 键 词：artemisinin inflammation neuroinflammation NEURODEGENERATION Alzheimer’s DISEASE Parkinson’s DISEASE Aβ ANTI-OXIDATION neuroprotection neural regeneration 

分 类 号：R[医药卫生]