Sodium butyrate prevents radiation-induced cognitive impairment by restoring pCREB/BDNF expression  

作　　者：Hae June Lee Yeonghoon Son Minyoung Lee Changjong Moon Sung Ho Kim In Sik Shin Miyoung Yang Sangwoo Bae Joong Sun Kim 

机构地区：[1]Division of Basic Radiation Bioscience,Korea Institute of Radiological&Medical Sciences(KIRMAS),Seoul,Republic of Korea [2]National Primate Research Center,Korea Research Institute of Bioscience and Biotechnology(KRIBB),Cheongju,Republic of Korea [3]College of Pharmacy,Kyungpook National University,Daegu,Republic of Korea [4]College of Veterinary Medicine,Veterinary Medical Research Institute,Chonnam National University,Gwangju,Republic of Korea [5]School of Medicine,Wonkwang University,Jeonbuk,Republic of Korea [6]Research Center,Dongnam Institute of Radiological&Medical Sciences(DIRAMS),Busan,Republic of Korea

出　　处：《Neural Regeneration Research》2019年第9期1530-1535,共6页中国神经再生研究（英文版）

基　　金：supported by the Nuclear Research and Development Program(NRF-2012M2A2A7012377,NRF-2015M2B2B1068627 and NRF-2015R1C1A2A01053041)of the National Research Foundation of Korea(NRF)funded by the Korean Government Ministry of Science,ICT&Future Planning

摘　　要：Sodium butyrate is a histone deacetylase inhibitor that affects various types of brain damages.To investigate the effects of sodium butyrate on hippocampal dysfunction that occurs after whole-brain irradiation in animal models and the effect of sodium butyrate on radiation exposure-induced cognitive impairments,adult C57BL/6 mice were intraperitoneally treated with 0.6 g/kg sodium butyrate before exposure to 10 Gy cranial irradiation.Cognitive impairment in adult C57BL/6 mice was evaluated via an object recognition test 30 days after irradiation.We also detected the expression levels of neurogenic cell markers(doublecortin)and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor.Radiation-exposed mice had decreased cognitive function and hippocampal doublecortin and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression.Sodium butyrate pretreatment reversed these changes.These findings suggest that sodium butyrate can improve radiation-induced cognitive dysfunction through inhibiting the decrease in hippocampal phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression.The study procedures were approved by the Institutional Animal Care and Use Committee of Korea Institute of Radiological Medical Sciences(approval No.KIRAMS16-0002)on December 30,2016.Sodium butyrate is a histone deacetylase inhibitor that affects various types of brain damages. To investigate the effects of sodium butyrate on hippocampal dysfunction that occurs after whole-brain irradiation in animal models and the effect of sodium butyrate on radiation exposure-induced cognitive impairments,adult C57BL/6 mice were intraperitoneally treated with 0.6 g/kg sodium butyrate before exposure to 10 Gy cranial irradiation. Cognitive impairment in adult C57BL/6 mice was evaluated via an object recognition test 30 days after irradiation. We also detected the expression levels of neurogenic cell markers(doublecortin)and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor. Radiation-exposed mice had decreased cognitive function and hippocampal doublecortin and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression. Sodium butyrate pretreatment reversed these changes. These findings suggest that sodium butyrate can improve radiation-induced cognitive dysfunction through inhibiting the decrease in hippocampal phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression. The study procedures were approved by the Institutional Animal Care and Use Committee of Korea Institute of Radiological Medical Sciences(approval No. KIRAMS16-0002) on December 30, 2016.

关 键 词：sodium BUTYRATE RADIOPROTECTOR ionizing radiation hippocampal damage cAMP response element binding BRAIN-DERIVED NEUROTROPHIC factor histone DEACETYLASE inhibitor neurogenesis 

分 类 号：R453[医药卫生—治疗学] R363[医药卫生—临床医学]