Prognostic significance of locally invaded sites and tissue types in patients with nasal extranodal natura-killer/T-cell lymphoma: a single-center retrospective analysis  

作　　者：Ge-Hong Dong Yong Li Ji-Yong Dong Xue Li Hong-Fei Wan Lei Yang Jing-Wen Wang Li-Ping Gong Yi-Hua Zhao Hong Zhang Zi-Fen Gao Hong-Gang Liu 

机构地区：[1]Departm ent of Pathology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China [2]Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China [3]Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Capital Medical University, Beijing 100730, China [4]Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China [5]Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China [6]Department of Pathology, School of Basic Medical of Capital Medical University, Beijing 100069, China

出　　处：《Chinese Medical Journal》2019年第11期1305-1313,共9页中华医学杂志（英文版）

摘　　要：Background:Extranodal natural killer/T-cell lymphoma (ENKTL), nasal type, is an aggressive entity within the World Health Organization classification of lymphoid tumors. The International Prognostic Index is reported to be prognostically meaningful for ENKTL, but lacks discriminatory power for stage Ⅰ/Ⅱ ENKTL with extensive local invasion. This study aimed to evaluate the prognostic effects of local invasion by site and tissue type in patients with ENKTL. Methods: We retrospectively analyzed data of 86 patients who were diagnosed with ENKTL by the Department of Pathology of Beijing Tongren Hospital from June 2002 to April 2016, and ascertained tumor infiltration of adjacent structures (AS), bone, and soft tissue for each patient, using physical findings and imaging scans. We used univariate and multivariate analysis to assess the association of each involved tissue or site with patients5 overall survival (OS). Results: Of the 86 patients, 71(82.6%) experienced invasion of AS, 22(25.6%) of soft tissue, and 26(30.2%) had bone involvement. Overall, patients with AS involvement did not show significantly shorter survival than those without AS involvement (Log rank X^2 = 1.177, P = 0.278);however, patients who had involved eyeballs or brains showed significantly lower 2-year OS rates than those without eyeball involvement (Log rank x^2 = 4.105, P = 0.043) or brain involvement (Log rank x^2 = 7.126, P = 0.008). Patients with involved local soft tissue or bones, respectively, showed lower 2-year OS rates than those without involved local soft tissue (Log rank x^2 = 10.390, P = 0.001) or bones (Log rank x^2 = 8.993, P = 0.003). Multivariate analysis showed that involvement of the cheek or facial muscles (hazard ratio, HR = 5.471, 95% confidence interval [Cl]: 1.466-20.416, P = 0.011) and the maxilla bone (HR = 6.120, 95% Cl: 1.517-24.694, P = 0.011) were significantly independent predictors of lower 2-year OS rates. Conclusions: Imaging can accurately detect ENKTL invasion of AS, soft tissue, and bone. Involvement of

关 键 词：Lymphoma Natural KILLER cells T-CELL Neoplasm INVASIVENESS Prognosis 

分 类 号：R[医药卫生]