姜黄素磷脂干粉工艺及其生物利用度研究  

A study on technology of curcumin phosphatidylcholine phytosome powder and bioavailability of curcumin

作　　者：刘洁瑜[1] 牛亚伟 李菁[1] 关伟健 袁诚[1] 唐顺之[1] 许文东[1] 蒙庚海 LIU Jie-yu;NIU Ya-wei;LI Jing;GUAN Wei-jian;YUAN Cheng;TANG Shun-zhi;XU Wen-dong;MENG Geng-hai(National Engineering Research Center for Modernization of Extraction and Separation Process of TCM,Guangzhou Hanfang Pharmaceutical Company Limited Guangzhou 510240)

机构地区：[1]中药提取分离过程现代化国家工程研究中心/广州白云山汉方现代药业有限公司

出　　处：《中国食品添加剂》2019年第7期121-128,共8页China Food Additives

摘　　要：目的:利用不同糊精改善姜黄素磷脂复合物的黏稠性,提高其稳定性、水溶出度、姜黄素生物利用度,拟定干粉的简单工艺,为保健食品等功能食品下游产品开发提供支持。方法:通过干粉制备的单因素实验、响应面方法及其和复合物的水溶出度、生物利用度考察,筛选糊精拟定工艺。结果:工艺简单合理可行,制备复合液后控制喷雾液中总含固量20%,抗性糊精添加量是复合物的2倍,进风温度160℃,进料速度8L/h。与复合物相比,复合物干粉的水溶性高6倍以上,峰值时间下峰浓度提高了近10倍,血药浓度时间曲线面积提高了6.7倍。结论:本研究工艺还能直接应用于各种特殊食品,例如保健食品产业中,具有广泛实用性、可操作性和可行性,产业效益-成本比高。有吸附包裹等功能的辅料,如可溶性膳食纤维抗性糊精与磷脂协同提高脂溶性大及生物利用度低的物质,例如姜黄素的稳定性、水溶性及生物利用度,为其下游功能性产品的安全多元化开发提供基础。Objective : It used kinds of dextrin to better viscosity of curcumin phosphatidylcholine phytosome and enhanced its stability, water solubility and bioavailability of curcumin to draft a technology of phytosome powder. The technology should be simple and as a base to support to explore functional products, like dietary supplement. Methods : A suitable kind of dextrin was chosen and a technology was drafted and proved by single factor experiment and response surface methodology in powder produce and comparative results of water solubility and bioavailability trials. Results : The technology of phytosome resistant dextrin powder was simple, reasonable and practicable. It' s specific that after producing the phytosome solution, we controlled the solid content of spray liquid was 20%, the content of resistant dextrin was twice of phytosome, the temperature of inlet wind was 160 ℃, the feed speed was 8 L/h. Comparative trials showed that their results of water solubility, Cmax and AUC0~∞ were higher than that of phytosome over 6 times, nearly 10 times and 6.7 times, respectively. Conclusions : The technology of the research can be used in the industrialized field of kinds of special food, like dietary supplement, directly. It is widely practicable, operational and feasible. It has high ratio of benefits-cost. It is speculated that take soluble dietary fiber resistant dextrin for example, accessory with functions like adsorption and coating can cooperatively with phosphatidylcholine to improve stability, water solubility and bioavailability of materials with high lipophilicity and poor bioavailability, like curcumin. The powder formulation can afford base of highly safe exploration of functional products with pluralism in produce.

关 键 词：姜黄素 磷脂 抗性糊精 协同提高 生物利用度 响应面法 

分 类 号：TS264.4[轻工技术与工程—发酵工程] Q545[轻工技术与工程—食品科学与工程]