Locoregional treatments for hepatocellular carcinoma: Current evidence and future directions  

作　　者：Riccardo Inchingolo Alessandro Posa Martin Mariappan Stavros Spiliopoulos 

机构地区：[1]Division of Interventional Radiology,Department of Radiology,Madonna delle Grazie Hospital,Matera 75100,Italy [2]Department of Radiology,King′s College Hospital,London SE5 9RS,United Kingdom [3]Department of Radiology,IRCSS Fatebenefratelli Hospital,Roma 00186,Italy [4]Interventional Radiology Department,Aberdeen Royal Infirmary Hospital,Aberdeen AB25 2ZN,United Kingdom [5]2nd Radiology Department,School of Medicine,National and Kapodistrian University of Athens,Chaidari Athens 12461,Greece

出　　处：《World Journal of Gastroenterology》2019年第32期4614-4628,共15页世界胃肠病学杂志（英文版）

摘　　要：Liver cancers are the second most frequent cause of global cancer-related mortality of which 90%are attributable to hepatocellular carcinoma(HCC).Despite the advent of screening programmes for patients with known risk factors,a substantial number of patients are ineligible for curative surgery at presentation with limited outcomes achievable with systemic chemotherapy/external radiotherapy.This has led to the advent of numerous minimally invasive options including but not limited to trans-arterial chemoembolization,radiofrequency/microwave ablation and more recently selective internal radiation therapy many of which are often the first-line treatment for select stages of HCC or serve as a conduit to liver transplant.The authors aim to provide a comprehensive overview of these various image guided minimally invasive therapies with a brief focus on the technical aspects accompanied by a critical analysis of the literature to assess the most up-to-date evidence from comparative systematic reviews and meta-analyses finishing with an assessment of novel combination regimens and future directions of travel.Liver cancers are the second most frequent cause of global cancer-related mortality of which 90% are attributable to hepatocellular carcinoma(HCC).Despite the advent of screening programmes for patients with known risk factors,a substantial number of patients are ineligible for curative surgery at presentation with limited outcomes achievable with systemic chemotherapy/external radiotherapy. This has led to the advent of numerous minimally invasive options including but not limited to trans-arterial chemoembolization,radiofrequency/microwave ablation and more recently selective internal radiation therapy many of which are often the first-line treatment for select stages of HCC or serve as a conduit to liver transplant. The authors aim to provide a comprehensive overview of these various image guided minimally invasive therapies with a brief focus on the technical aspects accompanied by a critical analysis of the literature to assess the most up-to-date evidence from comparative systematic reviews and meta-analyses finishing with an assessment of novel combination regimens and future directions of travel.

关 键 词：HEPATOCELLULAR carcinoma CIRRHOSIS Liver INTERVENTIONAL ONCOLOGY Transarterial chemo EMBOLIZATION Selective internal radiation therapy Ablation 

分 类 号：R[医药卫生]