Race, the microbiome and colorectal cancer  

作　　者：Kendra J Royston Babatunde Adedokun Olufunmilayo I Olopade 

机构地区：[1]Division of Hematology Oncology,University of Chicago,Chicago,IL 60637,United States [2]Center for Clinical Cancer Genetics and Global Health Department of Medicine,University of Chicago,Chicago,IL 60637,United States

出　　处：《World Journal of Gastrointestinal Oncology》2019年第10期773-787,共15页世界胃肠肿瘤学杂志（英文版）（电子版）

基　　金：acknowledge the University of Chicago Institute for Translational Medicine TL-1 program

摘　　要：In the past decade,more cancer researchers have begun to understand the significance of cancer prevention,which has prompted a shift in the increasing body of scientific literature.An area of fascination and great potential is the human microbiome.Recent studies suggest that the gut microbiota has significant roles in an individual’s ability to avoid cancer,with considerable focus on the gut microbiome and colorectal cancer.That in mind,racial disparities with regard to colorectal cancer treatment and prevention are generally understudied despite higher incidence and mortality rates among Non-Hispanic Blacks compared to other racial and ethnic groups in the United States.A comprehension of ethnic differences with relation to colorectal cancer,dietary habits and the microbiome is a meritorious area of investigation.This review highlights literature that identifies and bridges the gap in understanding the role of the human microbiome in racial disparities across colorectal cancer.Herein,we explore the differences in the gut microbiota,common short chain fatty acids produced in abundance by microbes,and their association with racial differences in cancer acquisition.In the past decade, more cancer researchers have begun to understand the significance of cancer prevention, which has prompted a shift in the increasing body of scientific literature. An area of fascination and great potential is the human microbiome. Recent studies suggest that the gut microbiota has significant roles in an individual’s ability to avoid cancer, with considerable focus on the gut microbiome and colorectal cancer. That in mind, racial disparities with regard to colorectal cancer treatment and prevention are generally understudied despite higher incidence and mortality rates among Non-Hispanic Blacks compared to other racial and ethnic groups in the United States. A comprehension of ethnic differences with relation to colorectal cancer, dietary habits and the microbiome is a meritorious area of investigation. This review highlights literature that identifies and bridges the gap in understanding the role of the human microbiome in racial disparities across colorectal cancer. Herein, we explore the differences in the gut microbiota, common short chain fatty acids produced in abundance by microbes, and their association with racial differences in cancer acquisition.

关 键 词：DIET EPIGENETICS MICROBIOME DISPARITIES COLORECTAL COLON Cancer 

分 类 号：R[医药卫生]