Study on the Inhibitory Effect of Scopoletin on Proliferation and Metastasis of Breast Cancer Cells  

作　　者：Xiaoyan LIU Juan LI Zhiqiang MEI 

机构地区：[1]The Research Center for Preclinical Medicine, Southwest Medical University

出　　处：《Agricultural Biotechnology》2019年第4期110-112,122,共4页农业生物技术（英文版）

基　　金：Supported by Education Department of Sichuan Province(14ZA0152);Health Department of Sichuan Province(130279)

摘　　要：[Objectives]This study was conducted to investigate the effect of scopoletin on the proliferation of breast cancer cell lines.[Methods]Cell viability,gene expression and cell cycle were measured by cell culture,RT-PCR and flow cytometry.The effects of different concentrations of scopoletin on proliferation and cell cycle of breast cancer cells were compared.[Results]After a certain period of time,the breast cancer cells showed different degrees of apoptosis,and the growth cycle was arrested in the G1 phase,which promoted the down-regulation of three genes in breast cancer metastasis.[Conclusions]The study proves that scopoletin inhibits the proliferation and metastasis of breast cancer cells in a concentration-and time-dependent manner.[Objectives] This study was conducted to investigate the effect of scopoletin on the proliferation of breast cancer cell lines. [Methods] Cell viability, gene expression and cell cycle were measured by cell culture, RT-PCR and flow cytometry. The effects of different concentrations of scopoletin on proliferation and cell cycle of breast cancer cells were compared. [Results] After a certain period of time, the breast cancer cells showed different degrees of apoptosis, and the growth cycle was arrested in the G1 phase, which promoted the down-regulation of three genes in breast cancer metastasis. [Conclusions] The study proves that scopoletin inhibits the proliferation and metastasis of breast cancer cells in a concentration-and time-dependent manner.

关 键 词：SCOPOLETIN BREAST cancer Inhibition STUDY 

分 类 号：R73[医药卫生—肿瘤]