Therapeutic potential of natural compounds from Chinese medicine in acute and subacute phases of ischemic stroke  

作　　者：Bei Zhang Kathryn ESaatman Lei Chen 

机构地区：[1]College of Public Health,Shaanxi University of Chinese Medicine,Xianyang,Shaanxi Province,China [2]Spinal Cord and Brain Injury Research Center,Department of Physiology,University of Kentucky,KY,USA

出　　处：《Neural Regeneration Research》2020年第3期416-424,共9页中国神经再生研究（英文版）

基　　金：supported by AHA Award 14SDG20480186(to LC);Kentucky Spinal Cord&Head Injury Research Trust Grant 14-12A(to KES);Startup Funds from Shaanxi University of Chinese Medicine to Young Investigators(1410170078)(to BZ)

摘　　要：Stroke is one of the leading causes of death and disability in adults worldwide,resulting in huge social and financial burdens.Extracts from herbs,especially those used in Chinese medicine,have emerged as new pharmaceuticals for stroke treatment.Here we review the evidence from preclinical studies investigating neuroprotective properties of Chinese medicinal compounds through their application in acute and subacute phases of ischemic stroke,and highlight potential mechanisms underlying their therapeutic effects.It is noteworthy that many herbal compounds have been shown to target multiple mechanisms and in combinations may exert synergistic effects on signaling pathways,thereby attenuating multiple aspects of ischemic pathology.We conclude the paper with a general discussion of the prospects for novel natural compound-based regimens against stroke.Stroke is one of the leading causes of death and disability in adults worldwide, resulting in huge social and financial burdens. Extracts from herbs, especially those used in Chinese medicine, have emerged as new pharmaceuticals for stroke treatment. Here we review the evidence from preclinical studies investigating neuroprotective properties of Chinese medicinal compounds through their application in acute and subacute phases of ischemic stroke, and highlight potential mechanisms underlying their therapeutic effects. It is noteworthy that many herbal compounds have been shown to target multiple mechanisms and in combinations may exert synergistic effects on signaling pathways, thereby attenuating multiple aspects of ischemic pathology. We conclude the paper with a general discussion of the prospects for novel natural compound-based regimens against stroke.

关 键 词：cell death HERBAL compound immune response ISCHEMIC stroke therapy NEUROPLASTICITY NEUROPROTECTION oxidative damage traditional Chinese medicine 

分 类 号：R74[医药卫生—神经病学与精神病学]