Anti-cancer effects of aloe-emodin:a systematic review  

作　　者：Brian Sanders Anna M.Ray Sharon Goldberg Tyler Clark H.Reginald McDaniel Steven E.Atlas Ashar Farooqi Janet Konefal Lucas C.Lages Johanna Lopez Ammar Rasul Eduard Tiozzo Judi M.Woolger John E.Lewis 

机构地区：[1]Department of Medicine,University of Miami Miller School of Medicine,Miami,Florida,United States [2]Glow Health,PA,Bay Harbor Islands,Florida,United States [3]Wellness Quest,LLC,Grand Prairie,Texas,United States [4]Department of Psychiatry&Behavioral Sciences,University of Miami Miller School of Medicine,Miami,Florida,United States [5]Department of Family Medicine,University of Miami Miller School of Medicine,Miami,Florida,United States

出　　处：《Journal of Clinical & Translational Research》2017年第3期1-14,共14页临床和转化研究

摘　　要：Background:Anthraquinones are a possible treatment option for oncological patients due to their anti-cancer properties.Cancer patients often exhaust a plethora of resources that ultimately fail to provide fully curative measures.Alternative treatments are subsequently sought in the hope of finding a therapeutic remedy.Potential regimens include aloe-emodin and its related derivatives.This review therefore summarizes the effects of aloe-emodin and other aloe components in light of their anti-proliferative and anti-carcinogenic properties.Methods:A systematic search was performed in PubMed for aloe-emodin and cancer in humans.Sixty abstracts of in vitro studies were selected and reviewed with subsequent screening of the full text.Thirty-eight articles were summarized.Results:Aloe-emodin possesses multiple anti-proliferative and anti-carcinogenic properties in a host of human cancer cell lines,with often multiple vital pathways affected by the same molecule.The most notable effects include inhibition of cell proliferation,migration,and invasion;cycle arrest;induction of cell death;mitochondrial membrane and redox perturbations;and modulation of immune signaling.The effects of aloe-emodin are not ubiquitous across all cell lines but depend on cell type.Conclusions:On the basis of this systematic review,the multiple consistent effects of aloe-emodin in human-derived cancer cell lines suggest that aloe-emodin is a potential anti-cancer agent that acts on cancer cells in a pleiotropic manner.Relevance for patients:Cancer patients often utilize alternative therapies as a result of suboptimal efficacy of conventional treatments.Aloe-emodin might become a therapeutic option for cancer patients if the basic research is confirmed in clinical trials.

关 键 词：ALOE VERA ANTHRAQUINONES ANTI-CANCER properties tumor biochemistry immune signaling in VITRO molecular pharmacology 

分 类 号：R73[医药卫生—肿瘤]