Monomeric and dimeric sesquiterpene lactones from Artemisia heptapotamica  

作　　者：Zhamilya Abilova YUAN Jie Janar Jenis TANG Chun-Ping YE Yang 

机构地区：[1]University of Chinese Academy of Sciences,Beijing 100049,China [2]State Key Laboratory of Drug Research,and Natural Products Chemistry Department,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China [3]Research Center for Medicinal Plants,Al-Farabi Kazakh National University,AI-Farabi ave.71,050040 Almaty,Republic of Kazakhstan [4]School of Life Science and Technology,Shanghailech University,Shanghai 201210,China

出　　处：《Chinese Journal of Natural Medicines》2019年第10期785-791,共7页中国天然药物（英文版）

基　　金：supported by the International Partnership Program of Chinese Academy of Sciences(No.153631KYSB20160004);the National Natural Science Foundation of China(Nos.81573305 and 81673327);the Ministry of Education and Science of the Republic of Kazakhstan(0118PK00458)

摘　　要：One new dimeric(1) and two monomeric sesquiterpene lactones(5 and 13), together with 10 known compounds(2-4, 6-12), were isolated from Artemisia heptapotamica collected in Almaty region of Kazakhstan. All compounds were isolated from this plant for the first time. The structures of the new compounds were mainly achieved by extensive analysis of MS, 1D and 2D NMR spectroscopic data, and ECD spectrum as well. The inhibitory activities of all isolates against activation of NF-κB induced by LPS were assessed on a THP1-Dual cell model. Some of them showed strong inhibitory activity with IC50 values ranging from 2 to 25μmol·L^-1.One new dimeric（1） and two monomeric sesquiterpene lactones（5 and 13）, together with 10 known compounds（2-4, 6-12）, were isolated from Artemisia heptapotamica collected in Almaty region of Kazakhstan. All compounds were isolated from this plant for the first time. The structures of the new compounds were mainly achieved by extensive analysis of MS, 1D and 2D NMR spectroscopic data, and ECD spectrum as well. The inhibitory activities of all isolates against activation of NF-κB induced by LPS were assessed on a THP1-Dual cell model. Some of them showed strong inhibitory activity with IC50 values ranging from 2 to 25μmol·L-1.

关 键 词：ARTEMISIA heptapotamica Artemisiane E Artemdubolide I Ajaniaolide B SESQUITERPENE LACTONE ANTI-INFLAMMATION 

分 类 号：R284.1[医药卫生—中药学]