financially supported by the Key Program of the National Natural Science Foundation of China(22137008);the Xingdian Yingcai Project(YNWR-KJLJ-2019-002);the Youth Innovation Promotion Association,CAs(2020386);the Reserve Talents of Young and Middle-aged Academic and Technical Leaders in Yunnan Province(202105AC160021).
Ten novel isocoumarins,including four pairs of enantiomers,were isolated from Artemisia dubia var.subdigitata(Asteraceae).Compounds 1,2 and 3a/3b possessed a unique 6/6/6-tricyclic system comprising an unusual 1-(2-me...
supported by the Key Program of National Natural Science Foundation of China(22137008);the Xingdian Yingcai Project(YNWR-KJLJ-2019-002);the Youth Innovation Promotion Association,CAS(2020386);the Reserve Talents of Young and Middle-aged Academic and Technical Leaders in Yunnan Province(202105AC160021).
Eight new guaiane-type sesquiterpenoid trimers,artemsieverolactones A—H,possessing unprecedented scaffolds via biocatalyzed[4+2]Diels−Alder cycloaddition reactions were identified from Artemisia sieversiana.Their str...
All nuclei in mesophyll cells of Artemisia marschalliana are located in vacuoles and occupy up to 90% of their volume. The ultrastructural organization of chromatin in nuclei shows different degrees of its decondensat...
This work was financially supported by the National Natural Science Foundation of China(Grant No.32001817);the Science and Technology Innovation Plan of Colleges and Universities of Shanxi Province(2020L0298);the College student innovation project of North University of China and the start-up funds for scientific research at North University of China(No.304-1101285714).
Background:Artemisia vulgaris,a medicinal aromatic plant,is widely used as a food item,tonic pharmaceutical,and cosmetic industry additive owing to its antibacterial,antihypertensive,hepatoprotective,antioxidant,and a...
This work was supported by the Key Program of the National Natural Science Foundation of China(No.22137008);the Xingdian Yingcai Project(No.YNWR-KJLJ-2019-002);the Youth Innovation Promotion Association,CAS(No.2020386);the Reserve Talents of Young and Middle-aged Academic and Technical Leaders in Yunnan Province(No.202105AC160021);the State Key Laboratory of Phytochemistry and Plant Resources in West China(P2021-ZZ06).
In pursuit of effective agents for hepatocellular carcinoma derived from the Artemisia species,this study built upon initial findings that an ethanol(EtOH)extract and ethyl acetate(EtOAc)fraction of the aerial parts o...
supported by the Key Program of National Natural Science Foundation of China(22137008);the Xingdian Yingcai Project(YNWR-KJLJ-2019-002);the Youth Innovation Promotion Association,CAS(2020386);the Reserve Talents of Young and Middle-aged Academic and Technical Leaders in Yunnan Province(202105AC160021).
17 new guaiane-type sesquiterpenoid dimers(GSDs),artemzhongdianolides B1—B17(1—17),were isolated from Artemisia zhongdianensis under the guidance of bioassay,and elucidated by spectral analyses(HRESIMS,1D and 2D NMR...
This work was financially supported by the Key Program of the National Natural Science Foundation of China(22137008);the Xingdian Yingcai Project(YNWR-KJLJ-2019-002);the Youth Innovation Promotion Association,CAS(2020386);the Reserve Talents of Young and Middle-aged Academic and Technical Leaders in YunnanProvince(202105AC160021).
Artemiprincepsolides A-F(1-6)were isolated from Artemisia princeps guided by bioactivity and elucidated by comprehensive spectral data and ECD calculation.Compounds 1-3 represented the first connecting model of germac...
This work was financially supported by the Key Program of the National Natural Science Foundation of China(22137008);the Xingdian Yingcai Project(YNWR-KJLJ-2019-002);the Youth Fund Program of the National Natural Science Foundation of China(82104040);the Funded by CAS Special Research Assistant(E12D9211Q1);the Youth Innovation Promotion Association,CAS(2020386);the Reserve Talents of Young and Middle-aged Academic and Technical Leaders in Yunnan Province(202105AC160021);Postdoctoral Directional Training Foundation of Yunnan Province(E131821261).The authors are grateful to Prof.Jian Ding,Prof.Hongchun Liu,and Dr.Hui Xu(Shanghai Institute of Materia Medica,Chinese Academy of Sciences)for their kind help in cytotoxic assay against THLE-2 cells,to Ms.Yaomei He and Senior Engineer Lian Yang(Kunming Institute of Botany,Chinese Academy of Sciences)for their help in network pharmacology analysis and the isothermal titration calorimetry and Surface Plasmon Resonance assay.
Dear Editor,Liver cancer as a common malignant tumor has become a major source of morbidity and mortality worldwide.1 Currently,four synthetic drugs and three monoclonal antibody drugs have been approved for the treat...