Pulmonary extranodal natural killer/T-cell lymphoma: clinical analysis of three cases  

作　　者：HU Qun 胡群(Dept Pulmon & Critic Care Med,Fuzhou General Clin Med Coll,Fujian Med Univ)

机构地区：[1]Dept Pulmon & Critic Care Med,Fuzhou General Clin Med Coll,Fujian Med Univ

出　　处：《China Medical Abstracts(Internal Medicine)》2019年第3期180-180,共1页中国医学文摘（内科学分册（英文版）

摘　　要：Objective To improve the understanding of pulmonary involvement of extranodal natural killer/T-cell lymphoma(ENKTL)by analyzing the clinical manifestations,imaging and pathological features of this disease.Methods Three cases of ENKTL,proven by pathological diagnosis in Fuzhou General Clinical Medical College of Fujian Medical University,were retrospectively analyzed.Results All of the 3 cases were males,aged 74,61 and 49 years,respectively.The main clinical symptoms included cold and fever.One patient had nasal congestion and runny nose.Chest CT showed multiple lung nodules(n=3),masses(n=2)and patchy shadows(n=2),with irregular lesions and clear boundaries.The 3 cases had been misdiagnosed as community acquired pneumonia,and treated with intravenous injection of moxifloxacin.ENKTL was confirmed by CT-guided percutaneous biopsy with immunohistochemical staining,which showed that 3 cases were positive for CD56,CD2,in situ hybridization for EBV encoded RNA(EBER),while negative for CD20,and 2 cases were positive for CD3,Granzyme B;and 1 case was positive for T-cell intracytoplasmic antigen-1.All 3 patients received chemotherapy,but 2 patients died,one of rejection 1 month later after bone marrow transplantation.One patient had improved after chemotherapy with follow-up.Conclusion ENKTL should be considered when patients presented with fever,multiple lung nodules or consolidations which were non-responsive to antibiotics.Lung biopsy was the key to diagnosis.

关 键 词：CASES KILLER CLINICAL 

分 类 号：R73[医药卫生—肿瘤]