Comparison of anti-inflammatory effects of intense pulsed light with tobramycin/dexamethasone plus warm compress on dry eye associated meibomian gland dysfunction  

作　　者：Yu-Fei Gao Rong-Jun Liu Ya-Xin Li Chenmilu Huang Yi-Yun Liu Chen-Xi Hu Hong Qi 

机构地区：[1]Department of Ophthalmology,Beijing Key Laboratory of Restoration of Damaged Ocular Nerve,Peking University Third Hospital,Beijing 100191,China [2]The First Hospital of Fangshan District,Beijing 102400,China [3]Beijing No.6 Hospital,Beijing 100007,China

出　　处：《International Journal of Ophthalmology(English edition)》2019年第11期1708-1713,共6页国际眼科杂志（英文版）

基　　金：Supported by National Natural Science Foundation of China (No. 81570813);the Lin Hu Scientific Research Foundation of Department of Ophthalmology, Peking University Third Hospital;the Scientific Research Foundation for the Excellent Returned Overseas Chinese Scholars, Peking University Third Hospital;the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry

摘　　要：AIM: To compare the anti-inflammatory effects of intense pulsed light(IPL) with tobramycin/dexamethasone plus warm compress through clinical signs and cytokines in tears.METHODS: Eighty-two patients with dry eye disease(DED) associated meibomian gland dysfunction(MGD) were divided into two groups. Group A was treated with IPL, and Group B was treated with tobramycin/dexamethasone plus warm compress. Ocular Surface Disease Index(OSDI), tear film breakup time(TBUT), corneal fluorescein staining(CFS), meibomian gland expressibility(MGE), meibum quality, gland dropout and tear cytokine levels were evaluated before treatment, 1 wk and 1 mo after treatment. RESULTS: TBUT in Group A was higher(P=0.035), and MGE score was lower than Group B at 1 mo(P=0.001). The changes of interleukin(IL)-17 A and IL-1β levels in tears were lower in Group A compared with that in Group B at 1 wk after treatment(P=0.05, P=0.005).CONCLUSION: Treatment with IPL can improve TBUT and MGE and downregulate levels of IL-17 A and IL-1β in tears of patients with DED associated MGD better than treatment with tobramycin/dexamethasone plus warm compress in one-month treatment period.AIM: To compare the anti-inflammatory effects of intense pulsed light(IPL) with tobramycin/dexamethasone plus warm compress through clinical signs and cytokines in tears.METHODS: Eighty-two patients with dry eye disease(DED) associated meibomian gland dysfunction(MGD) were divided into two groups. Group A was treated with IPL, and Group B was treated with tobramycin/dexamethasone plus warm compress. Ocular Surface Disease Index(OSDI), tear film breakup time(TBUT), corneal fluorescein staining(CFS), meibomian gland expressibility(MGE), meibum quality, gland dropout and tear cytokine levels were evaluated before treatment, 1 wk and 1 mo after treatment. RESULTS: TBUT in Group A was higher(P=0.035), and MGE score was lower than Group B at 1 mo(P=0.001). The changes of interleukin(IL)-17 A and IL-1β levels in tears were lower in Group A compared with that in Group B at 1 wk after treatment(P=0.05, P=0.005).CONCLUSION: Treatment with IPL can improve TBUT and MGE and downregulate levels of IL-17 A and IL-1β in tears of patients with DED associated MGD better than treatment with tobramycin/dexamethasone plus warm compress in one-month treatment period.

关 键 词：INTENSE pulsed light meibomian GLAND dysfunction dry eye disease INTERLEUKIN-17A INTERLEUKIN-1Β 

分 类 号：R73[医药卫生—肿瘤]