Radioiodinated tyrosine based carbon dots with efficient renal clearance for single photon emission computed tomography of tumor  

作　　者：Nian Liu Yiyue Shi Jingru Guo Hai Li Qiang Wang Menglin Song Zhiyuan Shi Le He Xinhui Su Jin Xie Xiaolian Sun 

机构地区：[1]State Key Laboratory of Natural Medicines,Key Laboratory of Drug Quality Control and Pharmacovigilance,Department of Pharmaceutical Analysis,China Pharmaceutical University,Nanjing 210009,China [2]Institute of Biological and Medical Imaging,Helmholtz Zentrum Miinchen and Technische Universitat Miinchen,Neuherberg 85764,Germany [3]State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine,School of Public Health,Xiamen University,Xiamen 361005,China [4]Institute of Functional Nano&Soft Materials(FUNSOM),Jiangsu Key Laboratory for Carbon-Based Functional Materials&Devices,Soochow University,Suzhou 215123,China [5]Department of Nuclear Medicine,Zhongshan Hospital Xiamen University,Xiamen 361004,China [6]Department of Chemistry,Bio-Imaging Research Center,University of Georgia,Athens,Georgia 30602,USA

出　　处：《Nano Research》2019年第12期3037-3043,共7页纳米研究（英文版）

基　　金：X.S.acknowledges the National Key Research and Development Program of China(No.2016YFA0203600);the National Natural Science Foundation of China(Nos.81971738 and 81571743);the Project Program of State Key Laboratory of Natural Medicines,and the China Pharmaceutical University(No.SKLNMZZRC05).

摘　　要：Nan oparticles with effective tumor accumulation and efficient renal clearance have attracted significant interests for clinical applications.Weprepared 2.5 nm tyrosine based carbon dots(TCDs)with phenolic hydroxyl groups on the surface for directly 125I labeling.The 125I labeledpolyethylene glycol(PEG)functionalized TCDs(125I-TCDPEGs)showed excellent radiochemical stability both in vitro and in vivo.Due to theenhanced permeability and retentio n effect,these 125I-TCDPEGs demonstrated a tumor accumulatio n around 4%-5%of the injected doseper gram(ID/g)for U87MG,4T1,HepG2 and MCF7 tumor-bearing mice at 1 h post-injection.Meanwhile,the 125I-TCDPEGs also could befast renally excreted,with less than 0.6%ID/g left in the liver and spleen within 24 h.These radioactive carb on dots not only can be used forcellular fluorescence imaging due to their intrinsic optical property,but are also effective single photon emission computed tomography(SPECT)imaging agents for tumor.Together with their excellent biocompatibility and stability,we anticipate these 125I-TCDPEGs of great potential for earlytumor diagnosis in clinic.Whafs more,our TCDPEGs are also proved to be feasible carriers for other iodine isotopes such as 127I and 131I fordifferent biomedical application.

关 键 词：RADIOIODINATION TYROSINE BASED carbon DOTS single PHOTON emissionrenal CLEARANCE 

分 类 号：R73[医药卫生—肿瘤]