海藻酸钠薰衣草精油微胶囊的制备及其性能研究  

Preparation and Performance Study of Sodium Alginate Lavender Essential Oil Microcapsules

作　　者：邓小丽[1] 胡明娟 金志刚 张猛 吴增宝[1] 沈于莉 陈文[1] DENG Xiao-li;HU Ming-juan;JIN Zhi-gang;ZHANG Meng;WU Zeng-bao;SHEN Yu-li;CHEN Wen(College of Pharmacy,Shihezi University,Shihezi 832000,China;New Drug Research&Development Company of NCPC,Shijiazhuang 050015,China)

机构地区：[1]石河子大学药学院,新疆石河子832000 [2]华北制药集团新药研究开发有限责任公司,河北石家庄050015

出　　处：《食品工业科技》2019年第23期47-53,共7页Science and Technology of Food Industry

基　　金：国家自然科学基金(81560714)

摘　　要：为了提高薰衣草精油的稳定性并且能使精油能控时控释释放。本实验考察了不同浓度的Span 85对乳液质量的影响,同时考察了去稳定剂、海藻酸钠浓度、CaCl2浓度、固化时间对薰衣草精油微胶囊制备效果的影响,进而得出适宜的薰衣草精油微胶囊制备条件,并对其性能进行了测定,同时研究了不同膜厚度和pH条件下薰衣草精油的释放情况。结果显示,分别加入乙醇、吐温20、乙醇加吐温20后微胶囊的膜厚度从20μm增加至56μm。释放结果表明,空白组在10 h内释放量达到了92%,乙醇组为80%,吐温20组为82%,但乙醇加吐温20组释放量仅为70%。此外还对微胶囊的载药量、包封率、粒径、形态等进行了考察,结果显示微胶囊的载药量在38.2%~57.2%之间,包封率在76.4%~92.8%之间,粒径处于45~84μm之间。综上所述,所制备的微胶囊膜厚度可控、形态圆整均一,薰衣草精油的释放时间长短可通过调节膜的厚度及释放介质的pH来实现。In order to improve the stability of lavender essential oil and enable the controlled release of essential oils. In this experiment,the effects of different concentrations of Span 85 on the quality of the emulsion were investigated.The effects of destabilizer,sodium alginate concentration,CaCl2 concentration and curing time on the preparation of lavender essential oil microcapsules were investigated.The preparation conditions of the suitable lavender essential oil microcapsules were obtained and their properties were measured.The release of lavender essential oil under different film thickness and pH conditions was also studied.The results showed that the membrane thickness of the microcapsules increased from 20 μm to 56 μm after adding ethanol,Tween 20,ethanol with Tween 20 respectively.The release results showed that the release of the blank group reached 92% within 10 h,the ethanol group was 80%,and the Tween 20 group was 82%,but the ethanol plus Tween 20 group released only 70%. In addition,the drug loading,encapsulation efficiency,particle size and morphology of the microcapsules were investigated. The results showed that the drug loading of the microcapsules was between 38.2% and 57.2%,and the encapsulation efficiency was between 76.4% and 92.8%.The particle size was between 45 and 84 μm.In summary,the prepared microcapsule film has a controlled thickness and a uniform shape,and the release time of the lavender essential oil can be achieved by adjusting the thickness of the film and the pH of the release medium.

关 键 词：薰衣草精油 微胶囊 海藻酸钠 反向分散凝胶技术 控制释放 

分 类 号：TS201.1[轻工技术与工程—食品科学]