Green tea catechins inhibit microglial activation which prevents the development of neurological disorders  

作　　者：Tahereh Farkhondeh Ali Mohammad Pourbagher-Shahri Milad Ashrafizadeh Silvia Llorens Folgado Ali Rajabpour-Sanati Mohammad Reza Khazdair Saeed Samarghandian 

机构地区：[1]Cardiovascular Diseases Research Center,Birjand University of Medical Sciences,Birjand,Iran [2]Faculty of Medicine,Birjand University of Medical Sciences,Birjand,Iran [3]Department of Basic Science,Faculty of Veterinary Medicine,University of Tabriz,Tabriz,Iran [4]Department of Medical Sciences,Faculty of Medicine of Albacete,Centro Regional de Investigaciones Biomedicas(CRIB),University of Castilla-La Mancha,Albacete,Spain [5]Healthy Ageing Research Center,Neyshabur University of Medical Sciences,Neyshabur,Iran [6]Department of Basic Medical Sciences,Neyshabur University of Medical Sciences,Neyshabur,Iran

出　　处：《Neural Regeneration Research》2020年第10期1792-1798,共7页中国神经再生研究（英文版）

摘　　要：The over-activated microglial cells induce neuroinflammation which has the main role in neurological disorders.The over-activated microglia can disturb neuronal function by releasing inflammatory mediators leading to neuronal dysfunctions and death.Thus,inhibition of over-activated microglia may be an effective therapeutic approach for modulating neuroinflammation.Experimental studies have indicated anti-neuroinflammatory effects of flavonoids such as green tea catechins.The current research was aimed to review the effect of green tea catechins in inhibiting microglial cells,inflammatory cascades,and subsequent neurological diseases.The over-activated microglial cells induce neuroinflammation which has the main role in neurological disorders. The over-activated microglia can disturb neuronal function by releasing inflammatory mediators leading to neuronal dysfunctions and death. Thus, inhibition of over-activated microglia may be an effective therapeutic approach for modulating neuroinflammation. Experimental studies have indicated anti-neuroinflammatory effects of flavonoids such as green tea catechins. The current research was aimed to review the effect of green tea catechins in inhibiting microglial cells, inflammatory cascades, and subsequent neurological diseases.

关 键 词：CATECHINS green tea MICROGLIA NEUROINFLAMMATION neurological disease 

分 类 号：R285.5[医药卫生—中药学]