Translational Regulation of Metabolic Dynamics during Effector-Triggered Immunity  

作　　者：Heejin Yoo George H.Greene Meng Yuan Guoyong Xu Derek Burton Lijing Liu Jorge Marques Xinnian Dong 

机构地区：[1]Howard Hughes Medical Institute,Department of Biology,Duke University,Box 90338,Durham,NC 27708,USA [2]National Key Laboratory of Crop Genetic Improvement,National Centre of Plant Gene Research(Wuhan),Huazhong Agricultural University,430070 Wuhan,China [3]Present address:Department of Plant Biology,Ecology,and Evolution,Oklahoma State University,Stillwater,OK 74078,USA [4]Present address:National Key Laboratory of Hybrid Rice,Institute for Advanced Studies(IAS),Wuhan University,Wuhan,Hubei 430072,China [5]Present address:Key Laboratory of Plant Development and Environment Adaptation Biology,Ministry of Education,School of Life Sciences,Shandong University,Qingdao,China [6]Present address:David H.Murdock Research Institute,Kannapolis,NC 28081,USA

出　　处：《Molecular Plant》2020年第1期88-98,共11页分子植物（英文版）

基　　金：This study was supported by grants from NIH R35GM118036-02,NSF IOS 1645589,and HHMI-GBMF(grant no.GBMF3032)to X.D.and a Hargitt fellowship to H.Y.

摘　　要：Recent studies have shown that global translational reprogramming is an early activation event in pattern-triggered immunity,when plants recognize microbe-associated molecular patterns.However,it is not fully known whether translational regulation also occurs in subsequent immune responses,such as effector-triggered immunity(ETI).In this study,we performed genome-wide ribosome profiling in Arabidopsis upon RPS2-mediated ETI activation and discovered that specific groups of genes were translationally regulated,mostly in coordination with transcription.These genes encode enzymes involved in aromatic amino acid,phenylpropanoid,camalexin,and sphingolipid metabolism.The functional significance of these components in ETI was confirmed by genetic and biochemical analyses.Our findings provide new insights into diverse translational regulation of plant immune responses and demonstrate that translational coordination of metabolic gene expression is an important strategy for ETI.

关 键 词：TRANSLATIONAL regulation RIBOSOME profiling effector-triggered immunity ETI PHENYLALANINE PHENYLPROPANOIDS HELPER receptors 

分 类 号：Q94[生物学—植物学]