HELPER

作品数：135被引量：373H指数：10
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相关领域：医药卫生更多>>
相关作者：卢大儒孙懿万磊郭杰刘健更多>>
相关机构：复旦大学中国科学院第二军医大学安徽中医药大学第一附属医院更多>>
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相关基金：国家自然科学基金中国博士后科学基金国家科技支撑计划上海市青年科技启明星计划更多>>
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Autoinhibition and cofactors of a helper NLR
《Science China(Life Sciences)》2025年第3期890-892,共3页Hongyuan Zheng Xuemin Zhou Chenyu Zhao Daowen Wang Zhengqing Fu 
supported by the National Science Foundation(IOS-2207677);the key research and development grant from Henan Province(232102111078).
Plants offer a plethora of benefits to human existence.However,in the natural world,plants encounter numerous biotic and abiotic pressures,including the presence of various pathogens that cause serious diseases on cro...
关键词：IMMUNITY diseases CROPS 
Huoxue Tongjiang decoction-resisted reflux esophagitis by activation stem cell factor/c-kit/interstitial cell of cajal pathway and regulating the T-helper 17/regulatory T-cells balance in rats
《Traditional Medicine Research》2024年第12期1-12,共12页Yan Liu Yan-Ping Tang Pei-Cai Li Lei Liu Xi Liu Si-Yu Liu Lei Yang 
supported by the National Natural Science Foundation of China(No.81573737 and 82074213);the science foundation of Tianjin Municipal Health Bureau(No.2023169 and 2021045);the Tianjin Municipal Health Commission Science and Technology Project(No.TJWJ2022QN057).
Background:Huoxue Tongjiang decoction(HXTJD)is an effective prescription for treating reflux esophagitis(RE).We investigated the effects of HXTJD on esophageal motility and mucosal inflammation in a rat RE model.Metho...
关键词：Huoxue Tongjiang decoction reflux esophagitis SCF/c-kit/ICC pathway Th17/Treg cell esophageal motility mucosal inflammation 
Correlation between circulating T follicular helper cell levels after infection and a decreased risk of COVID-19 re-infection
《Virologica Sinica》2024年第4期699-701,共3页Jinzhu Feng Zeyu Pu Rong Li Yuzhuang Li Xuewen Qin Hui Zhang Yiwen Zhang 
supported by the National Key R&D Program of Department of Science and Technology of China(2022YFC0870700);the Important Key Program of Natural Science Foundation of China(NSFC)(92169201);the Exchange Program of NSFC(82150710553);the Emergency Key Program of Guangzhou National Laboratory(EKPG21-24);the Key R&D Program of Department of Science and Technology of Guangdong(2022B1111020004)to H.Z.Natural Science Foundation of China(92169108 and 32000613);Guangdong Natural Science Funds for Distinguished Young Scholar(2023B1515020005)to Y.Z.
Dear Editor,As mass vaccination has been accomplished worldwide and a growing number of individuals have already been infected by SARS-CoV-2,understanding the incidence of subsequent re-infection is urgently required ...
关键词：INFECTION prevention subsequent 
B cell-reactive triad of B cells,follicular helper and regulatory T cells at homeostasis被引量：2
《Cell Research》2024年第4期295-308,共14页Yihan Lin Zurong Wan Bo Liu Jiacheng Yao Tianqi Li Fang Yang Jianhua Sui Yongshan Zhao Wanli Liu Xuyu Zhou Jianbin Wang Hai Qi 
funded in part by the National Key R&D Program of China(Ministry of Science and Technology,2018YFE0200300 to H.Q.);the National Natural Science Foundation of China(32130037,81621002 to H.Q.);the Natural Science Foundation of Beijing(grant 5224040 to B.L.).
Autoreactive B cells are silenced through receptor editing,clonal deletion and anergy induction.Additional autoreactive B cells are ignorant because of physical segregation from their cognate autoantigen.Unexpectedly,...
关键词：HOMEOSTASIS markedly CENTERS 
Screening of Streptomyces strains helping arbuscular mycorrhizal symbiosis against pepper(Capsicum annuum L.)Phytophthora blight
《Pedosphere》2024年第2期438-446,共9页Xin WANG Yifan LIU Baiping HE Minghui LI Xiangui LIN Fuyong WU Junli HU 
funded by the National Natural Science Foundation of China(No.42177304);the National Key R&D Program of China(No.2022YFD1500202);supported by the Youth Innovation Promotion Association of Chinese Academy of Sciences(No.2016285)。
Mycorrhiza helper bacteria(MHB)can promote the formation and functioning of arbuscular mycorrhizal(AM)symbiosis,but their role and application potential in coping with soil-borne diseases are still unclear.A 14-week g...
关键词：actinomycete strain blight severity Funneliformis caledonium mycorrhiza helper bacteria Phytophthora capsici root mycorrhizal colonization soil-bornedisease 
A T follicular helper cell origin for T regulatory type 1 cells被引量：1
《Cellular & Molecular Immunology》2023年第5期489-511,共23页Patricia Solé Jun Yamanouchi Josep Garnica Muhammad Myn Uddin Robert Clarke Joel Moro Nahir Garabatos Shari Thiessen Mireia Ortega Santiswarup Singha Debajyoti Mondal César Fandos Julio Saez-Rodriguez Yang Yang Pau Serra Pere Santamaria 
the Canadian Instutes of Health Research(CIHR)(FDN-353029,PJT-479040,PJT-479038,FRN-168480(with JDRF),DT4-179512);Genome Canada(GAPP program),the Praespero Foundation,the Alberta Diabetes Foundation,theISClll and FEDER(PIE14/00027,Pl15/0797);Ministerio de Ciencia e Innovacion of Spain(MCIN;PID2021-125493OB-I00);Generalitat de Catalunya(SGR and CERCA Programmes)and Red Espanola de Supercomputacion(RES,providing CSUC resources).P.Serra was an investigator of the Ramon y Cajal reintegration program and was supported by a JDRF Career Development Award.P.Sole and J.Garnica were supported by predoctoral studentships from FPU(MCIN).
Chronic antigenic stimulation can trigger the differentiation of antigen-experienced CD4+T cells into T regulatory type 1(TR1)cells,a subset of interleukin-10-producing Treg cells that do not express FOxP3.The identit...
关键词：T-regulatory type 1(TR1)cells autoimmunity T follicular helper(TFH)cells TRANSDIFFERENTIATION nanomedicine 
Effects of seasonal changes on T-helper 1/T-helper 2 immune balance and eczema onset in rats被引量：1
《Journal of Traditional Chinese Medical Sciences》2023年第1期64-72,共9页Hairong Zhang Leilei Liu Yike Sun Wenna Li Ruochong Wang Xiao Sun Guangqin Zhu Shuran Ma 
funded by the Fundamental Research Funds for the Central Universities(2020-JYB-ZDGG-016).
Objective: To explore the impact of seasonal changes on the T-helper 1(Th1)/T-helper 2(Th2) immune balance of the body in order to elucidate the internal immunological mechanisms underlying seasonal eczema.Methods: Ei...
关键词：ECZEMA SEASONALITY Long summer IMMUNIZATION Th1/Th2 MELATONIN Immunoglobulin E 
Moxibustion regulates T-regulatory/T-helper 17 cell balance by modulating the microRNA-221/suppressor of cytokine signaling 3 axis in a mouse model of rheumatoid arthritis被引量：10
《Journal of Integrative Medicine》2022年第5期453-462,共10页Chuang Zhao Xiao-yan Li Zun-yuan Li Miao Li Zhi-dan Liu 
This study was supported by the National Natural Science Foundation of China(No.81904284);Shanghai Talent Development Fund(No,2020086);Key Discipline Construction Fund of Baoshan Hospital of Integrated Traditional Chinese Medicine and Western Medicine,Shanghai(No.BSYYZDZK-2019-03 and No.BSYYZDZK-2019-04)。
Objective Rheumatoid arthritis(RA)progression is associated with the balance of T-regulatory(Treg)and T-helper 17(Th17)cells,while the role of microRNAs(miRs)in regulating Treg/Th17 cell balance has not been clarified...
关键词：Rheumatoid arthritis MOXIBUSTION MicroRNA-221 Suppressor of cytokine signaling 3 T-regulatory/T-helper 17 cell balance 
Pathogen-associated T follicular helper cell plasticity is critical in anti-viral immunity被引量：1
《Science China(Life Sciences)》2022年第6期1075-1090,共16页Han Feng Xiaohong Zhao Jenny Xie Xue Bai Weiwei Fu Hairong Chen Hong Tang Xiaohu Wang Chen Dong 
supported in part by the National Natural Science Foundation of China(31630022,31821003,31991170 and 31600718);Beijing Municipal Science and Technology Commission(Z181100001318007 and Z171100000417005)。
T follicular helper(Tfh)cells are critical in providing help for B cells in the germinal center reaction.Tfh cell plasticity,especially with regard to their expression of effector Th cytokines,has been described,but l...
关键词：T follicular helper(Tfh)cell PLASTICITY influenza infection IFN-γ IgG2 
Corrigendum:T Helper 1 and T Helper 2 Cytokines Differentially Modulate Expression of Filaggrin and its Processing Proteases in Human Keratinocytes
《Chinese Medical Journal》2022年第9期1026-1026,共1页
Follpwing the original aricle's publicatin,[1] the authors infrmed us of the ollowing rror. During the final compoundof high-resolution figures, a wrong picture was inadvertently put for the Western blot β-actin and ...
关键词：FIGURE corrected identical 
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