Preliminary study on fine structures of subcortical nuclei in rhesus monkeys by ex vivo 9.4 T MRI  

作　　者：Huan-Zhi Chen Hong-Yi Yang Kai Zhong Jia-Li Li 

机构地区：[1]Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences&Yunnan Province,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650223,China [2]High Magnetic Field Laboratory,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei,Anhui 230031,China [3]Kunming College of Life Science,University of Chinese Academy of Sciences,Kunming,Yunnan 650223,China [4]CAS Center for Excellence in Animal Evolution and Genetics,Chinese Academy of Sciences,Kunming,Yunnan 650223,China [5]CAS Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Hefei,Anhui 230031,China [6]Kunming Primate Research Center of the Chinese Academy of Sciences,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650223,China

出　　处：《Zoological Research》2020年第2期199-202,共4页动物学研究（英文）

基　　金：supported by the Chinese Academy of Sciences(Y406541141 and 1100050210);National Natural Science Foundation of China(91649119);National Natural Science Foundation of China(91649101);Ministry of Science and Technology of China(2015CB755605 and 2016YFC1305902)to J.L.L.;National Key Research and Development Program of China(2016YFC1300500-503);Hefei Science Center(2017HSC-KPRD003);Hefei Institutes of Physical Science(YZJJ201702)to K.Z。

摘　　要：DEAR EDITOR,Changes in fine structures of the brain over a life span can have robust effects on neural activity and brain function,which both play crucial roles in neurodegenerative diseases.Clinically,however,low-resolution MRI only provides limited information about fine brain structures.Here,using highresolution 9.4 T MRI,we established a set of structural images and explored the fine structures of the claustrum,hippocampus,amygdala complex,and subregions of the amygdala complex(BLA,including lateral,basal,and accessory basal subnuclei)in rhesus macaque(Macaca mulatta)brains.Based on these high-resolution images,we were able to discriminate the subregional boundaries accurately and,at the same time,obtain the volume of each brain nuclei.Thus,advanced high-resolution 9.4 T MRI not only provides a new strategy for early diagnosis of neurodegenerative diseases,but also provides the ability to observe fine structural changes in the brain across a life span.

关 键 词：DIAGNOSIS CLINICAL DISEASES 

分 类 号：R741[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学] R-332