Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation  

作　　者：Junbo Gao Xingjie Zhang Kun Shang Weimao Zhong Ruihan Zhang Xiaochang Dai Xiaoli Li Qi Wang Yan Zou Weilie Xiao 

机构地区：[1]Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education and Yunnan Province,School of Chemical Science and Technology,Yunnan University,Kunming 650091,China [2]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China

出　　处：《Chinese Chemical Letters》2020年第2期427-430,共4页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.81422046 and 21762048);the Yunnan Applicative and Basic Research Program(Nos.2015BC002,2018FY001 and 2018FA048);the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT_17R94);the Key Program of Natural Science of Yunnan Province to W.L.Xiao;the Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education(No.2017KF02);the Natural Science Foundation of Yunnan University(No.2017YDQN03);the Foundation of Yunnan Educational Committee(No.2018JS002)。

摘　　要：Callica rpabodinieri is a Chinese traditional medicine herb with anti-inflammatory activity in clinic.Herein,we report two new 9,10-seco and etherified abietane diterpenoids bodinieric acids J and K(1 and 2) and one known compound(3) isolated from the leaves and twigs of this plant.Their chemical structures were elucidated by detailed spectrometry data analysis and DP4+NMR calculation methods.Hypothetical biosynthetic pathways of 1-3 were preliminarily speculated.Compound 3 inhibited inflammasome activation and exhibited blockage of NLRP3 inflammasome activation at non-cytotoxic concentrations in vitro.Callica rpabodinieri is a Chinese traditional medicine herb with anti-inflammatory activity in clinic.Herein,we report two new 9,10-seco and etherified abietane diterpenoids bodinieric acids J and K(1 and 2) and one known compound(3) isolated from the leaves and twigs of this plant.Their chemical structures were elucidated by detailed spectrometry data analysis and DP4+NMR calculation methods.Hypothetical biosynthetic pathways of 1-3 were preliminarily speculated.Compound 3 inhibited inflammasome activation and exhibited blockage of NLRP3 inflammasome activation at non-cytotoxic concentrations in vitro.

关 键 词：CALLICARPA bodinieri Abietane-type DITERPENOIDS DP4+NMR calculation Anti-inflammation PYROPTOSIS NLRP3 INFLAMMASOME 

分 类 号：TQ461[化学工程—制药化工]