Suitability of the woodchuck HCC as a preclinical model for evaluation of intra-arterial therapies  

作　　者：Alexander Y.Kim Joseph H.Yacoub David H.Field Byoung Uk Park Bhaskar Kallakury Kyle E.Korolowicz Stephan Menne 

机构地区：[1]Department of Radiology,Medstar Georgetown University Hospital,Washington,District of Columbia [2]Department of Pathology and Laboratory Medicine,Medstar Georgetown University Hospital,Washington,District of Columbia [3]Department of Microbiology and Immunology,Georgetown University Medical Center,Washington,District of Columbia

出　　处：《Animal Models and Experimental Medicine》2020年第1期98-102,共5页动物模型与实验医学（英文）

摘　　要：The most commonly used preclinical models of hepatocellular carcinoma(HCC)are limited for use in testing of intra-arterial therapies such as transarterial chemoembolization and radioembolization.Issues encountered with the more commonly used animal models include dissimilarity in their disease development compared with humans and the size of the vasculature which can make intra-arterial therapy testing difficult or impossible.Here we describe the suitability of the woodchuck HCC model for testing of intra-arterial therapies.We describe the techniques for pre-embolization imaging assessment using CT and MRI,technical tips on performing angiography and embolization,and pathological assessment of treated liver.

关 键 词：ANGIOGRAPHY animal model HEPATOCELLULAR carcinoma WOODCHUCK 

分 类 号：R735.7[医药卫生—肿瘤] R-332[医药卫生—临床医学]