WOODCHUCK

作品数：11被引量：53H指数：4
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相关期刊：《Journal of Clinical and Translational Hepatology》《Journal of Cancer Therapy》《Virologica Sinica》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry更多>>
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Application of the woodchuck animal model for the treatment of hepatitis B virus-induced liver cancer被引量：1
《World Journal of Gastrointestinal Oncology》2021年第6期509-535,共27页Manasa Suresh Stephan Menne 
This review describes woodchucks chronically infected with the woodchuck hepatitis virus(WHV)as an animal model for hepatocarcinogenesis and treatment of primary liver cancer or hepatocellular carcinoma(HCC)induced by...
关键词：WOODCHUCK Hepatitis B virus Chronic infection Liver disease Hepatocellular carcinoma Cancer treatment 
Woodchuck hepatitis post-transcriptional regulatory element improves transgene expression and stability mediated by episomal vectors in CHO-K1 cells被引量：2
《Acta Biochimica et Biophysica Sinica》2020年第11期1285-1288,共4页Xiaoyin Wang Weili Zhang Yanlong Jia Meng Wang Dandan Yi Tian-yun Wang 
the grants from the National Nat-ural Science Foundation of China(No.U1804168);the Plan of Scientific and Technological Innovation Team for University,Henan Province,China(No.18IRTSTHN027);the Key Science and Tech-nology Project of Henan(No.192102310149);the Key Sci-entific Research Project of Universities of Henan Province(No.18A350008).
Gene therapy is an effective strategy for treating several diseases,and safe and efficient vector systems are the basis for gene therapy applications.The non-viral episomal vectors are preferred as a gene transfer too...
关键词：MEDIATED diseases INSERTION 
Suitability of the woodchuck HCC as a preclinical model for evaluation of intra-arterial therapies
《Animal Models and Experimental Medicine》2020年第1期98-102,共5页Alexander Y.Kim Joseph H.Yacoub David H.Field Byoung Uk Park Bhaskar Kallakury Kyle E.Korolowicz Stephan Menne 
The most commonly used preclinical models of hepatocellular carcinoma(HCC)are limited for use in testing of intra-arterial therapies such as transarterial chemoembolization and radioembolization.Issues encountered wit...
关键词：ANGIOGRAPHY animal model HEPATOCELLULAR carcinoma WOODCHUCK 
In Vitro Anti-hepatitis B Virus Activity of 2',3'-Dideoxyguanosine被引量：2
《Virologica Sinica》2018年第6期538-544,共7页Pinghu Zhang Shuo Zhai Jinhong Chang Ju-Tao Guo 
supported in part by the Program for New Century Excellent Talents in University (Program No. NCET-12-0975);the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry;Jiangsu Overseas research & training program for University Prominent Young and Middle-aged Teachers and Presidents (for Pinghu Zhang);Qinghai Province High-end Innovative Talent Thousand Talents Program (for Pinghu Zhang)
2',3'-dideoxyguanosine(DoG) has been demonstrated to inhibit duck hepatitis B virus(DHBV) replication in vivo in a duck model of HBV infection. In the current study, the in vitro antiviral effects of DoG on human and ...
关键词：HBV WOODCHUCK HEPATITIS virus(WHV) HEPATITIS B ANTIVIRAL NUCLEOSIDE ANALOGUES 
Molecular Cloning,Characterization and Expression Analysis of Woodchuck Retinoic Acid-Inducible GeneⅠ
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2016年第3期335-343,共9页严琦 刘钦 李蒙蒙 李芳慧 朱彬 Jun-zhong WANG 王俊忠 卢银平 刘嘉 吴珺 郑昕 陆蒙吉 王宝菊 杨东亮 
supported by grants from the National Science and Technology Major Project for Infectious Diseases of China(No.2012ZX10004503);the National Natural Science Foundation of China(No.81101248,No.81261120397 and No.81371828);the Deutsche Forschungs-gemeinschaft(Transregio TRR60)
Cytosolic retinoic acid-inducible gene I（RIG-I） is an important innate immune RNA sensor and can induce antiviral cytokines, e.g., interferon-β（IFN-β）. Innate immune response to hepatitis B virus（HBV） plays a ...
关键词：retinoic acid-inducible gene I woodchuck woodchuck hepatitis virus 
Asymptomatic Hepadnaviral Persistence and Its Consequences in the Woodchuck Model of Occult Hepatitis B Virus Infection被引量：7
《Journal of Clinical and Translational Hepatology》2015年第3期211-219,共9页Patricia M.Mulrooney-Cousins Tomasz I.Michalak 
The studies were supported by operating grants MA-9256,MT-11262,RO-15174 and MOP-14818 from the Canadian Institutes of Health Research;formerly the Medical Research Council of Canada
Woodchuck hepatitis virus (WHV) is molecularly and pathogenically closely related to hepatitis B virus (HBV).Both viruses display tropism towards hepatocytes and cells of the immune system and cause similar liver path...
关键词：Hepatitis B Occult hepatitis B virus infection Woodchuck model of hepatitis B Woodchuck hepatitis virus Secondary occult infection Primary occult infection Consequences of occult hepadnaviral infection Hepatocellular carcinoma 
The Effect of Fasting on PET Imaging of Hepatocellular Carcinoma被引量：6
《Journal of Cancer Therapy》2013年第2期562-567,共6页Nathan Tenley David J. Corn Lewis Yuan Zhenghong Lee 
The clinical utility of positron emission tomography (PET) imaging for liver cancer applications is not clearly defined either for diagnosis or treatment assessment. Previous clinical studies demonstrated that fluorod...
关键词：ACETATE FDG HEPATOCELLULAR Carcinoma WOODCHUCK POSITRON Emission Tomography 
Recent Advances in Research on Hepadnaviral Infection in the Woodchuck Model
《Virologica Sinica》2008年第2期107-115,共9页Ina Schulte E-juan ZHANG Zhong-ji MENG Rong-juan PEI Mengji LU Michael Roggendorf 
Deutsche Forschungsgemeinschaft (Lu 669/2-1, GRK1045/1, and Lu 669/5-1)
The woodchuck model is an excellent animal model to study hepadnaviral infection. The new progresses in this model made possible to examine the T-cell mediated immune responses in acute and chronic hepadnaviral infect...
关键词：Chronic hepatitis B Woodchuck hepatitis virus （WHV） Hepatitis B virus （HBV） 
The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infection被引量：23
《World Journal of Gastroenterology》2007年第1期104-124,共21页Stephan Menne Paul J Cote 
Supported by contract N01-AI-05399 to the College of Veterinary Medicine, Cornell University from the National Institute of Allergy and Infectious Diseases. PC and SM also have been supported by contract N01-AI-95390 to the Georgetown University Medical Center, Georgetown University from the National Institute of Allergy and Infectious Diseases
This review describes the woodchuck and the woodchuck hepatitis virus (WHV) as an animal model for pathogenesis and therapy of chronic hepatitis B virus (HBV) infection and disease in humans. The establishment of wood...
关键词：WOODCHUCK Woodchuck hepatitis virus Hepatitis B virus Neonatalacquired infection Adult-acquired infection Resolution CHRONICITY Humoral immune response Cellular immune response Antiviraltherapy Immunotherapy Combination therapy Hepatocellular carcinoma 
Cross-species hybridization of woodchuck hepatitis virus-induced hepatocellular carcinoma using human oligonucleotide microarrays被引量：1
《World Journal of Gastroenterology》2006年第29期4646-4651,共6页Paul W Anderson Bud C Tennant Zhenghong Lee 
an NIH grant CA095307 (Z. Lee, PI)by the Gene Expression Array Core Facility of the Comprehensive Cancer Center of Case Western Reserve University and University Hospitals of Cleveland, No. P30 CA43703
AIM： To demonstrate the feasibility of using woodchuck samples on human microarrays, to provide insight into pathways involving positron emission tomography （PET） imaging tracers and to identify genes that could be...
关键词：Cross-species hybridization Gene expression Woodchuck hepatitis virus Hepatocellular carcinoma WOODCHUCK Marmota monax 
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