全氟化合物污染现状及其与肝型脂肪酸结合蛋白相互作用研究进展  

Current Pollution Situation of Perfluorinated Compounds in Waters and Foodstuffs and Recent Progress in Understanding Their Interactions with Liver Fatty Acid Binding Protein

作　　者：方国康[1] 徐建明[2] 李若慧[1] 蒋丹[1] 黄迎春[1] FANG Guokang;XU Jianming;LI Ruohui;JIANG Dan;HUANG Yingchun(Beijing Key Laboratory of Biomass Waste Resource Utilization,College of Biochemical Engineering,Beijing Union University,Beijing 100023,China;Jiangsu Key Laboratory for Eco-agricultural Biotechnology around Hongze Lake,Huaiyin Normal University,Huai’an 223300,China)

机构地区：[1]北京联合大学生物化学工程学院,生物质废弃物资源化利用北京市重点实验室,北京100023 [2]淮阴师范学院江苏省环洪泽湖生态农业生物技术重点实验室,江苏淮安223300

出　　处：《食品科学》2020年第7期329-335,共7页Food Science

基　　金：北京市自然科学基金重点项目(6181001);江苏省环洪泽湖生态农业生物技术重点实验室开放课题(HZHLAB1705)。

摘　　要：全氟化合物(perfluorinated compounds,PFCs)是一类含氟的烃类化合物,由于其具有相当稳定的物理化学性质,被广泛应用于食品、医药、农业等行业中;但其可降解性差,对大气、土壤甚至生物体都会造成不可预估的危害。本文总结了PFCs在水体、植物以及水产品、肉和蛋等食品中的污染现状,综述了PFCs与肝型脂肪酸结合蛋白(liver fatty acid binding protein,L-FABP)相互作用干扰脂代谢,进而导致与肥胖、胰岛素耐受性、二型糖尿病和高脂血症相关的脂毒性,探讨PFCs与L-FABP的结合特征以及造成生物累积性和肝脏毒性的可能机制。进一步研究PFCs与体内9种类型FABPs的结合活性,对了解PFCs的体内分布和生理毒性具有重要意义。Perfluorinated compounds(PFCs), a class of fluorine-containing hydrocarbon compounds, are widely used in food, pharmaceutical and agricultural industries for its relatively stable physicochemical properties. But its poor degradability could bring about unpredictable damages to the atmosphere, soil and even organisms. In this paper, the current pollution situation of PFCs in water, plants, fishery products, meat and eggs is summarized, and the interaction between PFCs and liver fatty acid binding protein(L-FABP), which interferes with lipid metabolism and consequently leads to obesity, insulin resistance, type 2 diabetes and hyperlipidemia is reviewed together with the binding characteristics of PFCs with L-FABP and the possible mechanisms for the bioaccumulation and hepatotoxicity of PFCs. It is of great significance to understand the distribution in vivo and physiological toxicity of PFCs. Thus, the binding of PFCs with nine types of FABPs needs further investigation.

关 键 词：全氟化合物 食品污染 肝型脂肪酸结合蛋白 相互作用 

分 类 号：TS201.6[轻工技术与工程—食品科学]