CAF-induced placental growth factor facilitates neoangiogenesis in hepatocellular carcinoma  

作　　者：Zhongjian Liu Mingmei Chen Rongce Zhao Yuan Huang Fei Liu Bo Li Yang Qin 

机构地区：[1]Department of Biochemistry and Molecular Biology,West China School of Basic Medical Sciences&Forensic Medicine,Sichuan University,Chengdu 610041,China [2]Division of Liver Transplantation,Department of Surgery,West China Hospital,Sichuan University,Chengdu 610041,China

出　　处：《Acta Biochimica et Biophysica Sinica》2020年第1期18-25,共8页生物化学与生物物理学报（英文版）

基　　金：This work was supported by the grant from the National Natural Science Foundation of China(No.81172372).

摘　　要：As a highly malignant tumor,hepatocellular carcinoma(HCC)is the third leading cause of cancer-related deaths worldwide.In most HCC patients,the development of HCC begins with hepatitis,which is followed by fibrosis and cirrhosis before progressing to HCC.Cancer-associated fibroblasts(CAFs),which are generally believed to be derived from activated hepatic stellate cells(HSCs),are highly involved in the development of HCC through the secretion of cytokines and angiogenic factors.The results of our study showed that a considerable number of CAFs highly expressed CD90 and were enriched in HCC tissues.Bioinformatics analysis of the transcriptome of HCC tissues revealed that placental growth factor(PIGF)is significantly correlated with CD90 expression.The isolated primary CAFs and activated HSCs overexpressed PIGF and CD90.In addition,the results of gene expression profiling interactive analysis based on The Cancer Genome Atlas showed that high levels of both PIGF and CD90 are correlated with tumor angiogenesis markers(CD31,CD34,and CD105)and predict poor HCC patient prognosis.In summary,our results suggest that CAFs can generate PIGF and may provide an effective target for CAFs-reguIated neoangiogenesis in HCC.

关 键 词：CD90 cancer-associated FIBROBLAST PLACENTAL growth factor NEOANGIOGENESIS HEPATOCELLULAR carcinoma 

分 类 号：R735.7[医药卫生—肿瘤]