Microglia Research in the 100th Year Since Its Discovery  

作　　者：Anthony DUmpierre Long-Jun Wu 

机构地区：[1]Department of Neurology,Mayo Clinic,Rochester,MN 55905,USA [2]Department of Neuroscience,Mayo Clinic,Jacksonville,FL 32224,USA [3]Department of Immunology,Mayo Clinic,Rochester,MN 55905,USA

出　　处：《Neuroscience Bulletin》2020年第3期303-306,共4页神经科学通报（英文版）

基　　金：by a National Institutes of Health(NIH)F32 grant(NS114040);the Mayo Foundation and NIH R01 grants(NS088627 and NS112144).

摘　　要：In 1919,Pio del Rio-Hortega first described a class of cells residing in the brain with a tiny soma and branched architecture distinguishable from astrocytes and neurons.These cells,called microglia or mesoglia,have come to be appreciated as resident immune cells in the central nervous system(CNS).In the year 2019,we review the three most recent advances in microglia research in this 100th year since their discovery(Fig.1).We first discuss their transcriptional diversity,which allows us to appreciate the heterogeneity of microglia across species,development,diseases,and brain regions.We also highlight recent stem cell-based approaches that allow us to study human microglia.

关 键 词：DISEASES GLIA APPRECIATE 

分 类 号：R741[医药卫生—神经病学与精神病学]