Artificial Nanoscale Erythrocytes from Clinically Relevant Compounds for Enhancing Cancer Immunotherapy  

作　　者：Wenquan Ou Kang Sik Nam Dae Hoon Park Jungho Hwang Sae Kwang Ku Chul Soon Yong Jong Oh Kim Jeong Hoon Byeon 

机构地区：[1]College of Pharmacy,Yeungnam University,Gyeongsan 38541,Republic of Korea [2]School of Mechanical Engineering,Yonsei University,Seoul 03722,Republic of Korea [3]College of Korean Medicine,Daegu Haany University,Gyeongsan 38610,Republic of Korea [4]School of Mechanical Engineering,Yeungnam University,Gyeongsan 38541,Republic of Korea

出　　处：《Nano-Micro Letters》2020年第7期156-174,共19页纳微快报（英文版）

基　　金：supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Science,ICT and future Planning(2018R1A2A1A05020683);supported by the NRF(2018R1A2A2A05021143)grant funded by the Korean Government;the Medical Research Center Program(2015R1A5A2009124)through the NRF funded by MSIP.

摘　　要：Because of enhanced e cacy and lower side e ects,cancer immunotherapies have recently been extensively investigated in clinical trials to overcome the limitations of conventional cancer monotherapies.Although engineering attempts have been made to build nanosystems even including stimulus nanomaterials for the e cient delivery of antigens,adjuvants,or anticancer drugs to improve immunogenic cancer cell death,this requires huge R&D e orts and investment for clinically relevant findings to be approved for translation of the nanosystems.To this end,in this study,an air–liquid two-phase electrospray was developed for stable bubble pressing under a balance between mechanical and electrical parameters of the spray to continuously produce biomimetic nanosystems consisting of only clinically relevant compounds[paclitaxel-loaded fake blood cell Eudragit particle(Eu-FBCP/PTX)]to provide a conceptual leap for the timely development of translatable chemo-immunotherapeutic nanosystems.This was pursued as the e cacy of systems for delivering anticancer agents that has been mainly influenced by nanosystem shape because of its relevance to transporting behavior to organs,blood circulation,and cell–membrane interactions.The resulting Eu-FBCP/PTX nanosystems exhibiting phagocytic and micropinocytic uptake behaviors can confer better e cacy in chemo-immunotherapeutics in the absence and presence of anti-PD-L1 antibodies than similar sized PTX-loaded spherical Eu particles(Eu-s/PTX).

关 键 词：Cancer IMMUNOTHERAPIES Air–liquid two-phase ELECTROSPRAY Paclitaxel-loaded FAKE blood cell EUDRAGIT particle Translatable chemo-immunotherapeutic NANOSYSTEMS Anti-PD-L1 antibodies 

分 类 号：R730.5[医药卫生—肿瘤] TB383[医药卫生—临床医学]