The pharmacological and toxicological action of strychnine on central nervous system  

作　　者：Taotao Wang Qian Yang Rong Gao Jianxiu Zhai Jun Yin 

机构地区：[1]School of Traditional Chinese Material Medica,Shenyang Pharmaceutical University,Shenyang 110016,PR China

出　　处：《Asian Journal of Traditional Medicines》2020年第2期76-86,共11页亚洲传统医药（英文）

摘　　要：Strychnine is the main bioactive constituent responsible for the pharmacological and toxic properties of strychnos nux-vomica L.(Loganiaceae),which is known for severe neurotoxicity.Although its toxic threshold is easy to be reached and it is liable to cause poisoning,the effect of strychnine on the central nervous system(CNS)is crucial for its application in clinic.Therefore,the impacts of pharmacology and toxicology of strychnine on CNS have generated increasing interests.In this short review,we summarize the pharmacological activities,neurotoxicology,underlying mechanisms of the strychnine poisoning,and discuss the pharmacokinetics properties of strychnine.These findings could provide beneficial information for facilitating future mechanism research of neurotoxicity of strychnine and developing drugs to remedy neurotoxicity in the clinic.

关 键 词：STRYCHNINE PHARMACOLOGICAL activities NEUROTOXICITY mechanisms 

分 类 号：O62[理学—有机化学]