Radiofrequency combined with immunomodulation for hepatocellular carcinoma: State of the art and innovations  

作　　者：Adriano Carneiro da Costa Mikael Sodergren Kumar Jayant Fernando Santa Cruz Duncan Spalding Madhava Pai Nagy Habib 

机构地区：[1]Department of Surgery and Cancer,Faculty of Medicine,Hammersmith Hospital,Imperial College London,London W120NN,United Kingdom

出　　处：《World Journal of Gastroenterology》2020年第17期2040-2048,共9页世界胃肠病学杂志（英文版）

摘　　要：Hepatocellular carcinoma(HCC)is the most common primary liver tumor and has been considered a very immunogenic tumor.The treatment with radiofrequency ablation(RFA)has been established as the standard ablative therapy for early HCC,and is currently recognized as the main ablative tool for HCC tumors<5 cm in size;however,progression and local recurrence remain the main disadvantages of this approach.To solve this clinical problem,recent efforts were concentrated on multimodal treatment,combining different strategies,including the combination of RFA and immunotherapy.This article reviewed the combination treatment of RFA with immunotherapy and found that this treatment strategy leads to an increased response of anti-tumor T cells,significantly reduces the risk of recurrence and improves survival rates compared to RFA alone.This review highlighted scientific evidence that supports the current recommendations for pre-clinical studies,and discuss the need for further research on this topic.

关 键 词：HEPATOCELLULAR carcinoma RADIOFREQUENCY ablation IMMUNOTHERAPY Liver cancer Combined MODALITY therapy STATE-OF-THE-ART review 

分 类 号：R735.7[医药卫生—肿瘤]