Ethnic differences in genetic polymorphism associated with irritable bowel syndrome  

作　　者：Qi-Yun Xiao Xiu-Cai Fang Xiao-Qing Li Gui-Jun Fei 

机构地区：[1]Department of Gastroenterology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China

出　　处：《World Journal of Gastroenterology》2020年第17期2049-2063,共15页世界胃肠病学杂志（英文版）

基　　金：Supported by the Program of International S&T Cooperation,No.2014DFA31850;National Natural Science Foundation of China,No.81870379.

摘　　要：Genetic polymorphism is associated with irritable bowel syndrome(IBS)in terms of susceptibility and clinical manifestations.Previous studies have shown that genetic polymorphism might play a key role in the onset and progression of IBS by modulating components of its pathogenesis such as the gut-brain axis,gastrointestinal motility,inflammatory activity,and immune status.Although underlying pathophysiological mechanisms have not been fully clarified,the potential ethnic differences that are present in worldwide genetic studies of IBS deserve attention.This review surveyed numerous studies focusing on IBSassociated single nucleotide polymorphisms,and investigated the ethnic disparities revealed by them.The results demonstrate the need for more attention on ethnic factors in IBS-related genetic studies.Taking ethnic backgrounds into accounts and placing emphasis on disparities potentially ascribed to ethnicity could help lay a solid and generalized foundation for transcultural,multi-ethnic,or secondary analyses in IBS,for example,a meta-analysis.Broader genetic studies considering ethnic factors are greatly needed to obtain a better understanding of the pathophysiological mechanisms of IBS and to improve the prevention,intervention,and treatment of this disease.

关 键 词：IRRITABLE BOWEL syndrome ETHNICITY Genetic POLYMORPHISM Single NUCLEOTIDE POLYMORPHISM Genome-wide association Pathogenesis 

分 类 号：R574.4[医药卫生—消化系统]