Role of gut microbiota in cardiovascular diseases  

作　　者：Marko Novakovic Amit Rout Thomas Kingsley Robert Kirchoff Amteshwar Singh Vipin Verma Ravi Kant Rahul Chaudhary 

机构地区：[1]Department of Internal Medicine,Sinai Hospital of Baltimore,Baltimore,MD 21215,United States [2]Department of Internal Medicine,Division of Hospital Internal Medicine,Mayo Clinic,Rochester,MN 55905,United States [3]Department of Internal Medicine,Division of Hospital Medicine,Johns Hopkins University School of Medicine,Baltimore,MD 21205,United States [4]Department of Internal Medicine,Medical University of South Carolina/AnMed Campus,Charleston,SC 29425,United States [5]Division of Endocrinology,Diabetes and Nutrition,Medical University of South Carolina/Anmed Campus,Anderson,SC 29621,United States

出　　处：《World Journal of Cardiology》2020年第4期110-122,共13页世界心脏病学杂志（英文版）（电子版）

摘　　要：The human gut is colonized by a community of microbiota,primarily bacteria,that exist in a symbiotic relationship with the host.Intestinal microbiota-host interactions play a critical role in the regulation of human physiology.Deleterious changes to the composition of gut microbiota,referred to as gut dysbiosis,has been linked to the development and progression of numerous diseases,including cardiovascular disease(CVD).Imbalances in host-microbial interaction impair homeostatic mechanisms that regulate health and can activate multiple pathways leading to CVD risk factor progression.Most CVD risk factors,including aging,obesity,dietary patterns,and a sedentary lifestyle,have been shown to induce gut dysbiosis.Dysbiosis is associated with intestinal inflammation and reduced integrity of the gut barrier,which in turn increases circulating levels of bacterial structural components and microbial metabolites,including trimethylamine-N-oxide and short-chain fatty acids,that may facilitate the development of CVD.This article reviews the normal function and composition of the gut microbiome,mechanisms leading to the leaky gut syndrome,its mechanistic link to CVD and potential novel therapeutic approaches aimed towards restoring gut microbiome and CVD prevention.As CVD is the leading cause of deaths globally,investigating the gut microbiota as a locus of intervention presents a novel and clinically relevant avenue for future research.

关 键 词：Cardiovascular DISEASE CORONARY artery DISEASE GUT MICROBIOTA DYSBIOSIS THROMBOSIS 

分 类 号：R54[医药卫生—心血管疾病]